Metronidazole B. Braun

Metronidazole, the active ingredient in Metronidazole B. Braun, is a nitroimidazole antibiotic presented as an injectable solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal infections in adult patients.

GNH USA supplies Metronidazole B. Braun as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Metronidazole is employed to manage infections caused by anaerobic bacteria and susceptible protozoa. - Anaerobic bacterial infections: effective against infections caused by anaerobic organisms, reducing bacterial load. - Bacterial vaginosis: restores normal vaginal flora by eliminating pathogenic anaerobes. - Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing transmission. - Intra‑abdominal infections: controls polymicrobial infections within the abdominal cavity. - Pelvic inflammatory disease: targets anaerobic pathogens contributing to pelvic infection. - Skin and soft tissue infections: treats infected wounds where anaerobes are present.

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Metallic taste: transient metallic sensation in the mouth. - Headache: mild to moderate headache. - Diarrhea: loose stools, usually self‑limiting. - Abdominal pain: cramping or discomfort. - Dizziness: occasional light‑headedness.

Serious or Rare Side Effects: - Seizures: rare neurologic events requiring immediate care. - Peripheral neuropathy: tingling or numbness in extremities. - Stevens‑Johnson syndrome: severe skin reaction with blistering. - Anaphylaxis: life‑threatening allergic response. - Severe liver injury: marked elevation of hepatic enzymes. - Neutropenia: significant drop in white blood cell count.

Metronidazole requires careful monitoring in specific clinical situations. - Renal function assessment: adjust therapy in patients with impaired kidney function. - Hepatic monitoring: observe liver enzymes during prolonged treatment. - Alcohol avoidance: prevent disulfiram‑like reactions by abstaining from alcohol. - Pregnancy considerations: use only if benefits outweigh potential risks, as safety data are limited. - Elderly patients: start with lower doses and monitor for toxicity. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Alcohol: may cause severe flushing, tachycardia, and hypotension. - Warfarin: can enhance anticoagulant effect, increasing bleeding risk. - Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely): - Carbamazepine: may reduce metronidazole plasma concentrations. - Oral contraceptives: efficacy may be decreased, consider alternative contraception.