Metronidazole Accord Healthcare

Metronidazole, the active ingredient in Metronidazole Accord Healthcare, is a nitroimidazole antibiotic presented as an oral tablet for oral use. It treats a range of anaerobic bacterial and protozoal infections in adult and pediatric patients as prescribed by a healthcare professional.

GNH USA supplies Metronidazole Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa. It is indicated for the following conditions: - Bacterial vaginosis: restores normal vaginal flora and relieves discharge. - Trichomoniasis: eliminates Trichomonas vaginalis and resolves symptoms. - Amoebiasis: eradicates Entamoeba histolytica causing intestinal disease. - Giardiasis: clears Giardia lamblia infection and reduces diarrhea. - Anaerobic bacterial infections: targets mixed‑flora infections such as intra‑abdominal or pelvic abscesses. - Clostridioides difficile infection: reduces toxin‑producing bacteria and improves colitis symptoms.

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Metallic taste: transient metallic sensation in the mouth. - Diarrhea: loose stools during therapy. - Abdominal pain: cramping or discomfort. - Headache: mild to moderate headache. - Dizziness: occasional light‑headedness.

Serious or Rare Side Effects: - Seizures: rare neurologic events. - Peripheral neuropathy: tingling or numbness in extremities. - Severe allergic reactions: rash, swelling, or anaphylaxis. - Stevens‑Johnson syndrome: serious skin eruption. - Pseudomembranous colitis: Clostridioides difficile overgrowth. - Hepatic toxicity: elevated liver enzymes or jaundice.

Before prescribing Metronidazole, clinicians should consider several safety factors. - Pregnancy: safety not established; use only if benefits outweigh risks. - Breastfeeding: drug may be excreted in milk; caution advised. - Alcohol: avoid concurrent intake to prevent disulfiram‑like reaction. - Renal impairment: dose adjustment may be required in severe dysfunction. - Hepatic impairment: monitor liver function and adjust dose if needed. - Store at room temperature: keep in original container, protect from moisture and heat.

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Alcohol: may cause severe flushing, tachycardia, and hypotension. - Warfarin: increased anticoagulant effect, risk of bleeding. - Lithium: heightened lithium toxicity. - Cimetidine: elevated metronidazole plasma levels. - Phenobarbital: reduced metronidazole effectiveness.

Moderate Interactions (Monitor Closely): - Erythromycin: may increase metronidazole concentrations. - Phenytoin: may lower metronidazole levels. - Theophylline: potential increase in theophylline toxicity.