GNH USA

Europe — EMA

Metronidazole Hikma Farmacêutica (Portugal)

GNH USA supplies Metronidazole Hikma Farmacêutica (Metronidazole), a nitroimidazole antibiotic for bacterial vaginosis, trichomoniasis, and anaerobic

Metronidazole

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What is Metronidazole?

Metronidazole, the active ingredient in Metronidazole Hikma Farmacêutica, is a nitroimidazole antibiotic presented as an intravenous solution for parenteral use. It treats anaerobic bacterial and certain protozoal infections in adults and children as prescribed.

GNH USA supplies Metronidazole Hikma Farmacêutica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured product availability across multiple regions, adhering to stringent regulatory standards and providing reliable logistics for global distribution.

What is Metronidazole used for?

Metronidazole is a nitroimidazole antibiotic used to treat infections caused by anaerobic bacteria and certain protozoa.

- Bacterial vaginosis: eliminates the anaerobic bacterial overgrowth, reducing discharge and odor. - Trichomoniasis: eradicates Trichomonas vaginalis, relieving itching and discharge. - Amoebiasis: clears intestinal Entamoeba histolytica infection, preventing dysentery. - Clostridioides difficile infection: suppresses toxin‑producing C. difficile, aiding resolution of colitis. - Anaerobic bacterial infections: treats intra‑abdominal, pelvic, skin and soft‑tissue infections caused by anaerobes.

What are the side effects of Metronidazole?

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild stomach upset. - Metallic taste: transient metallic sensation. - Headache: mild to moderate headache. - Diarrhea: loose stools.

Serious or Rare Side Effects: - Seizures: neurologic events, especially with high doses. - Peripheral neuropathy: tingling or numbness in extremities. - Stevens‑Johnson syndrome: severe skin reaction.

What precautions apply to Metronidazole?

When prescribing Metronidazole, several safety considerations should be observed. - Assess renal and hepatic function: dose may need adjustment in impairment. - Avoid alcohol: concurrent intake can cause a disulfiram‑like reaction. - Monitor for neurotoxicity: discontinue if seizures or neuropathy develop. - Use with caution in pregnancy: category B, but limit to situations where benefits outweigh risks. - Review concomitant medications: potential for interaction with warfarin or lithium. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

What does Metronidazole interact with?

Metronidazole can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid): - Alcohol: may cause severe flushing, tachycardia, hypotension. - Warfarin: increased anticoagulant effect, risk of bleeding.

Moderate Interactions (Monitor Closely): - Lithium: may raise lithium levels, monitor serum concentration. - Cimetidine: can increase metronidazole plasma levels. - Phenobarbital: may reduce metronidazole effectiveness. - Oral contraceptives: may reduce efficacy, advise additional contraception.

Frequently asked questions

What conditions is Metronidazole Hikma Farmacêutica used to treat?+
Metronidazole Hikma Farmacêutica is indicated for bacterial vaginosis, trichomoniasis, amoebiasis, Clostridioides difficile infection, and a range of anaerobic bacterial infections such as intra‑abdominal, pelvic, skin and soft‑tissue infections.
How does Metronidazole work against microorganisms?+
The drug penetrates susceptible cells and its nitro group is reduced under low‑oxygen conditions, forming reactive radicals that damage DNA. This interferes with nucleic acid synthesis, leading to microbial cell death, which is why it is effective against anaerobic bacteria and certain protozoa.
What determines the dose of Metronidazole Hikma Farmacêutica?+
The prescribed dose is determined by the treating clinician based on the specific infection, patient weight, age, renal and hepatic function, and severity of disease. No fixed regimen is provided here; the prescriber sets the appropriate dosing schedule.
Is Metronidazole safe during pregnancy or breastfeeding?+
Metronidazole is classified as pregnancy category B, indicating that animal studies have not shown risk but there are limited human data. It may be used when the potential benefit justifies the potential risk. Caution is advised during breastfeeding, and the prescriber should evaluate the risk‑benefit ratio.
How do I order Metronidazole Hikma Farmacêutica from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Metronidazole compare with other antibiotics for anaerobic infections?+
Metronidazole is a nitroimidazole that specifically targets anaerobic organisms through DNA damage, offering rapid bactericidal activity. Compared with broad‑spectrum agents like clindamycin, it often has fewer drug‑interaction concerns and a well‑established safety profile, though resistance patterns and individual patient factors guide the choice of therapy.
What are the recommended storage conditions for Metronidazole Hikma Farmacêutica?+
The product should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen. Maintaining the cold‑chain ensures stability and potency of the intravenous solution until it is administered.
How is Metronidazole Hikma Farmacêutica administered?+
Metronidazole Hikma Farmacêutica is supplied as an intravenous solution and is administered by slow infusion into a vein under the supervision of a qualified healthcare professional. The infusion rate and duration are determined by the prescriber based on the indication and patient condition.
What are the most serious risks to watch for while using Metronidazole?+
Serious adverse events include seizures, peripheral neuropathy, and severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for neurological symptoms, new skin eruptions, or any signs of hypersensitivity, and therapy should be discontinued promptly if these occur.
Who should not use Metronidazole Hikma Farmacêutica?+
Metronidazole should be avoided in individuals with a known hypersensitivity to the drug or other nitroimidazoles. Caution is also required for patients with severe hepatic impairment, and it should not be given concurrently with alcohol due to the risk of a disulfiram‑like reaction.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metronidazole
Route
Intravenous Use
Manufacturer
Hikma Farmacêutica (Portugal), S.A.
Origin
EU

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