Metronidazol Braun

Metronidazole, the active ingredient in Metronidazol Braun, is a Nitroimidazole antibiotic presented as an intravenous solution for Intravenous use. It treats anaerobic bacterial and protozoal infections in adult patients.

GNH USA supplies Metronidazol Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa.

- Anaerobic bacterial infections: eradicates susceptible anaerobes and helps resolve tissue infection. - Trichomoniasis, amoebiasis, giardiasis: eliminates the protozoal organisms responsible for gastrointestinal and genitourinary disease. - Bacterial vaginosis: reduces pathogenic anaerobes to restore normal vaginal flora.

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Metallic taste: transient metallic sensation in the mouth. - Headache: mild to moderate headache. - Diarrhea: loose stools during therapy. - Abdominal pain: crampy discomfort. - Dizziness: light‑headed feeling.

Serious or Rare Side Effects: - Seizures: convulsive episodes, especially with high plasma levels. - Peripheral neuropathy: tingling or numbness in extremities. - Severe allergic reaction (anaphylaxis): rash, swelling, airway compromise. - Stevens‑Johnson syndrome: severe skin blistering. - Hepatic toxicity: elevated liver enzymes or hepatitis. - Neutropenia: marked reduction in white blood cells.

Before initiating therapy, consider patient‑specific factors and monitor for adverse events. - Renal impairment: adjust dose or monitor plasma concentrations. - Hepatic impairment: use with caution and monitor liver function tests. - Alcohol consumption: avoid to prevent disulfiram‑like reaction. - Concomitant warfarin: monitor INR closely for enhanced anticoagulation. - Pregnancy: prescribe only if benefits outweigh potential risks. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Metronidazole can interact with several medicines, requiring either avoidance or careful monitoring.

Major Interactions (Avoid): - Alcohol: may cause severe flushing and vomiting. - Warfarin: potentiates anticoagulant effect, increasing bleeding risk. - Lithium: may raise lithium levels, risking toxicity. - CYP450 inhibitors (e.g., cimetidine): increase metronidazole concentrations. - Disulfiram: additive disulfiram‑like reactions.

Moderate Interactions (Monitor Closely): - Phenytoin: reduces metronidazole levels, possibly decreasing efficacy. - Carbamazepine: lowers metronidazole concentrations. - Rifampin: induces metabolism, reducing drug exposure. - Theophylline: may increase theophylline levels. - Oral contraceptives: may reduce contraceptive effectiveness.