Metronidazol B. Braun

Metronidazole, the active ingredient in Metronidazol B. Braun, is a nitroimidazole antibiotic presented as an injectable solution for intravenous use. It treats anaerobic bacterial infections, Clostridioides difficile infection, bacterial vaginosis and amoebiasis in adult patients.

GNH USA supplies Metronidazol B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Metronidazole acts against anaerobic microorganisms and protozoa, making it useful for several infection types.

- Anaerobic bacterial infections: effective in eradicating susceptible anaerobic organisms. - Clostridioides difficile infection: reduces toxin‑producing bacteria and alleviates colitis. - Bacterial vaginosis: restores normal vaginal flora by targeting Gardnerella and related species. - Amoebiasis: eliminates Entamoeba histolytica trophozoites in invasive disease.

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Metallic taste: transient alteration of taste perception. - Headache: mild to moderate intensity. - Diarrhea: loose stools, usually self‑limiting. - Abdominal pain: cramping or discomfort. - Dizziness: occasional light‑headedness.

Serious or Rare Side Effects: - Seizures: rare neurologic events requiring immediate care. - Severe allergic reaction: rash, itching, swelling, or anaphylaxis. - Stevens‑Johnson syndrome: severe skin and mucous membrane involvement. - Hepatotoxicity: elevated liver enzymes or jaundice. - Peripheral neuropathy: tingling or numbness in extremities. - Neutropenia: marked reduction in white blood cells.

Metronidazole requires careful use in specific clinical situations.

- Renal impairment: assess kidney function and consider dose adjustment. - Hepatic dysfunction: monitor liver enzymes and adjust therapy if needed. - Alcohol consumption: avoid alcohol due to disulfiram‑like reaction. - Pregnancy: prescribe only when benefits outweigh potential risks. - Concurrent warfarin therapy: monitor INR closely for increased anticoagulation. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Metronidazole can interact with several medicines, influencing safety or efficacy.

Major Interactions (Avoid): - Disulfiram: may cause severe disulfiram‑like reaction. - Alcohol: can precipitate intense flushing, nausea, and vomiting. - Lithium: increased risk of lithium toxicity.

Moderate Interactions (Monitor Closely): - Warfarin: potentiates anticoagulant effect, monitor INR. - Phenytoin: may reduce metronidazole plasma levels. - Cimetidine: can increase metronidazole concentrations.