Metronidazol Actavis

Metronidazole, the active ingredient in Metronidazol Actavis, is a nitroimidazole antibiotic presented as a tablet for oral use. It treats infections caused by anaerobic bacteria and certain protozoa in adults and children as prescribed. GNH USA supplies Metronidazol Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metronidazole is a nitroimidazole antibiotic used to treat infections caused by anaerobic bacteria and protozoa.

- Bacterial vaginosis: eliminates the anaerobic bacteria responsible for the condition, relieving discharge and odor. - Trichomoniasis: eradicates Trichomonas vaginalis, curing the sexually transmitted infection. - Amoebiasis: destroys Entamoeba histolytica trophozoites, treating intestinal and extra‑intestinal disease. - Giardiasis: clears Giardia lamblia infection, relieving diarrhoea and abdominal cramps. - Clostridioides difficile infection: suppresses toxin‑producing C. difficile, aiding resolution of colitis. - Anaerobic bacterial infections: targets a broad range of anaerobes in intra‑abdominal, pelvic, skin and soft‑tissue infections.

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea - Metallic taste - Headache - Diarrhoea - Abdominal pain - Loss of appetite

Serious or Rare Side Effects: - Seizures - Peripheral neuropathy - Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome) - Pseudomembranous colitis - Hepatotoxicity - Blood dyscrasias (e.g., neutropenia, thrombocytopenia)

Before prescribing Metronidazol Actavis, clinicians should consider several safety aspects.

- Renal function: assess kidney status, dose may need adjustment in severe impairment. - Hepatic function: monitor liver enzymes, especially in patients with pre‑existing liver disease. - Alcohol consumption: advise patients to avoid alcohol due to disulfiram‑like reactions. - Pregnancy: use only if benefits outweigh potential risks; safety data are limited. - Concomitant medications: review for interactions that may increase toxicity or reduce efficacy. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Metronidazol Actavis can affect, or be affected by, several other medicines.

Major Interactions (Avoid): - Alcohol: may cause severe flushing, tachycardia, and hypotension. - Warfarin: potentiates anticoagulant effect, increasing bleeding risk. - Lithium: can raise lithium serum levels, leading to toxicity. - Cyclosporine: may increase cyclosporine concentrations, risking nephrotoxicity. - Carbamazepine: reduces metronidazole levels, potentially compromising efficacy.

Moderate Interactions (Monitor Closely): - Phenytoin: may lower metronidazole concentrations. - Phenobarbital: can increase metabolism of metronidazole. - Rifampin: induces hepatic enzymes, reducing metronidazole exposure. - Cimetidine: may increase metronidazole plasma levels. - Oral contraceptives: may reduce hormonal efficacy, advise additional contraception.