GNH USA

Europe — EMA

Metrogel

GNH USA supplies Metrogel (Metronidazole), a nitroimidazole gel for rosacea treatment in adults.

Metronidazole

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What is Metronidazole?

Metronidazole, the active ingredient in Metrogel, is a nitroimidazole presented as a gel for topical use. It treats rosacea and related facial skin inflammation in adults.\n\nGNH India supplies Metrogel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metronidazole used for?

Metronidazole is an antiprotozoal nitroimidazole used primarily in dermatology for inflammatory skin disorders.\n\nPapulopustular rosacea: reduces papules and pustules.\nErythematotelangiectatic rosacea: diminishes facial redness and visible blood vessels.\nGeneralized facial erythema: improves overall skin tone and reduces persistent redness.

What are the side effects of Metronidazole?

Topical metronidazole may cause local skin reactions, most of which are mild and reversible.\n\nCommon Side Effects:\n- Burning sensation at the application site\n- Stinging or tingling feeling\n- Dryness or flaking of the skin\n- Itching or mild pruritus\n- Redness or mild erythema\n- Slight swelling or edema\n\nSerious or Rare Side Effects:\n- Severe allergic reaction (e.g., angioedema)\n- Contact dermatitis with blistering\n- Extensive skin ulceration\n- Anaphylaxis (rare)\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis\n- Persistent discoloration of the skin

What precautions apply to Metronidazole?

Use Metrogel only as directed and consider patient‑specific factors before application.\n\nPregnancy: safety not established; avoid unless benefit outweighs risk.\nBreastfeeding: unknown safety; consult a healthcare professional.\nBroken skin: do not apply to open wounds or irritated areas.\nConcurrent alcohol use: may increase local irritation.\nEye contact: avoid applying near the eyes; rinse thoroughly if contact occurs.\nStore at room temperature: keep in the original container, protect from moisture and light.

What does Metronidazole interact with?

Topical metronidazole may interact with other agents applied to the same skin area.\n\nMajor Interactions (Avoid):\n- Systemic metronidazole: concurrent use may increase systemic exposure.\n- Other topical nitroimidazoles: avoid combined use to prevent additive irritation.\n\nModerate Interactions (Monitor Closely):\n- Topical corticosteroids: may mask local irritation signs.\n- Alcohol‑based moisturizers: can enhance skin burning.\n- Photosensitizing agents: increase risk of sunburn when exposed to UV light.

Frequently asked questions

What is Metrogel used for?+
Metrogel is a topical gel containing metronidazole that is primarily prescribed to manage the signs of rosacea, including facial redness, papules, and pustules. It helps reduce inflammation and improve skin appearance in affected adults.
How does metronidazole work in Metrogel?+
Metronidazole is reduced inside anaerobic microorganisms and skin cells, producing reactive nitro radicals that break DNA strands and inhibit nucleic acid synthesis. This action reduces bacterial overgrowth and suppresses inflammatory mediators, leading to decreased redness and lesions.
What is the usual dose of Metrogel?+
The dosage of Metrogel is determined by the prescribing healthcare professional. Typically, a thin layer is applied to the affected facial areas once or twice daily, but the exact regimen should follow the prescriber’s instructions.
Is Metrogel safe to use during pregnancy or breastfeeding?+
Safety of Metrogel in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk, and the decision should be made in consultation with a qualified healthcare provider.
How do I order Metrogel from GNH USA?+
To order Metrogel, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Metrogel compare with other rosacea treatments?+
Metrogel’s active ingredient, metronidazole, is a nitroimidazole with anti‑inflammatory and antimicrobial properties. Compared with azelaic acid or ivermectin creams, metronidazole is often well‑tolerated and effective for papulopustular rosacea, though individual response may vary.
What are the storage and handling requirements for Metrogel?+
Metrogel should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing the gel.
How is Metrogel applied?+
Clean and gently pat the affected facial skin dry. Apply a thin, even layer of Metrogel to the rosacea‑affected areas, usually once or twice daily, as directed by the prescriber. Avoid contact with eyes, lips and broken skin.
What are the most serious risks associated with Metrogel?+
Serious risks, though rare, include severe allergic reactions such as angioedema, contact dermatitis with blistering, extensive skin ulceration, and life‑threatening conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice worsening skin reactions.
Who should not use Metrogel?+
Metrogel should not be used by individuals with known hypersensitivity to metronidazole or any component of the formulation, on broken or severely irritated skin, or in conjunction with systemic metronidazole without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Metronidazole
Route
Cutaneous Use
Manufacturer
Galderma (U.K.) Limited
Origin
EU

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