Metran

Metronidazole, the active ingredient in Metran, is a nitroimidazole antibiotic presented as an oral dosage form for systemic use. It is employed to treat infections caused by susceptible anaerobic bacteria and certain protozoa in both adult and pediatric patients. The medication is indicated for conditions such as bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, and a range of anaerobic bacterial infections, providing targeted antimicrobial activity.

GNH USA supplies Metran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare providers worldwide.

Metronidazole is used to treat infections caused by anaerobic bacteria and certain protozoa. - Bacterial vaginosis: eradicates the causative anaerobic bacteria and restores normal vaginal flora. - Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms and preventing recurrence. - Amoebiasis: destroys Entamoeba histolytica trophozoites in intestinal and extra‑intestinal disease. - Giardiasis: clears Giardia lamblia infection, reducing diarrhoea and abdominal discomfort. - Anaerobic bacterial infections: targets susceptible anaerobes in intra‑abdominal, pelvic and skin‑soft tissue infections.

Metronidazole may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Nausea - Metallic taste - Headache - Diarrhoea

Serious or Rare Side Effects: - Seizures - Peripheral neuropathy - Severe allergic reactions, including Stevens‑Johnson syndrome

When prescribing metronidazole, clinicians should consider several precautionary measures to ensure safe use. - Renal impairment: assess renal function and adjust dose if necessary. - Hepatic disease: use with caution in patients with liver dysfunction. - Alcohol consumption: avoid alcohol during treatment and for at least 48 hours after completion. - Pregnancy: evaluate risk‑benefit ratio before use in pregnant women. - Concomitant anticoagulants: monitor for increased bleeding tendency. - Store at ambient temperature: keep in original container, protect from moisture and light.

Metronidazole can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Alcohol: may cause a disulfiram‑like reaction with flushing, nausea and vomiting. - Warfarin: can potentiate anticoagulant effect and increase bleeding risk. - Lithium: may raise lithium serum concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely): - Phenytoin: may reduce metronidazole plasma levels, decreasing effectiveness. - Cimetidine: can increase metronidazole concentrations, heightening side‑effect potential. - Phenobarbital: may enhance metabolism of metronidazole, lowering its therapeutic levels.