Metother

Methotrexate, the active ingredient in Metother, is an antimetabolite presented as a subcutaneous injection for subcutaneous use. It is employed to manage rheumatoid arthritis, moderate to severe plaque psoriasis, several malignant neoplasms, and to medically terminate ectopic pregnancy in suitable patients.

GNH USA supplies Metother as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide across multiple regions.

Methotrexate is an antimetabolite used in several immune‑mediated and oncologic conditions.

Rheumatoid arthritis: reduces joint inflammation and slows disease progression. Psoriasis: improves skin lesions and decreases plaque formation. Certain cancers (e.g., acute lymphoblastic leukemia, osteosarcoma): interferes with tumor cell proliferation. Ectopic pregnancy: terminates trophoblastic tissue to avoid surgical intervention.

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Fatigue: general feeling of tiredness. - Oral mucositis: soreness or ulceration of the mouth lining. - Cytopenia: reduced white blood cells, red blood cells or platelets. Serious or Rare Side Effects: - Hepatotoxicity: significant liver enzyme elevation or fibrosis. - Pulmonary fibrosis: progressive scarring of lung tissue. - Severe infection: opportunistic infections due to immune suppression. - Bone marrow failure: aplastic anemia or pancytopenia.

Before initiating Metother, several precautions should be observed to minimise risk.

Pregnancy: contraindicated (Category X) – avoid use in pregnant women. Renal function: assess baseline creatinine and adjust dose in impairment. Liver function: monitor transaminases regularly; avoid in severe hepatic disease. Infection risk: screen for active infections and vaccinate appropriately before therapy. Concurrent immunosuppressants: evaluate combined immunosuppression to reduce infection risk. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Methotrexate interacts with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid): - NSAIDs: increase methotrexate toxicity by reducing renal clearance. - Penicillins (e.g., ampicillin): may potentiate myelosuppression. - Sulfonamides: can elevate plasma methotrexate levels. - Live vaccines: risk of uncontrolled infection due to immunosuppression. Moderate Interactions (Monitor Closely): - Azathioprine: additive bone marrow suppression. - Leflunomide: enhanced hepatotoxic potential. - Warfarin: variable effect on anticoagulation; monitor INR. - Tetracyclines: may increase hepatic toxicity.