GNH USA

Europe — EMA

Metotab

GNH USA supplies Metotab (Methotrexate), a disease-modifying antirheumatic drug for rheumatoid arthritis, psoriasis and certain cancers.

Methotrexate

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What is Methotrexate?

Methotrexate, the active ingredient in Metotab, is an antimetabolite (folate antagonist) presented as an oral tablet for oral use. It is employed to treat rheumatoid arthritis, psoriasis, certain cancers and ectopic pregnancy in appropriate patients.

GNH USA supplies Metotab as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Methotrexate used for?

Metotab (methotrexate) acts as a folate antagonist and is used in several disease categories. - Rheumatoid arthritis: reduces joint inflammation and slows disease progression. - Psoriasis: improves skin lesions and decreases scaling. - Acute lymphoblastic leukemia: interferes with malignant cell proliferation. - Non‑Hodgkin lymphoma: contributes to remission of lymphoid malignancies. - Ectopic pregnancy: medically terminates non‑viable implantation.

What are the side effects of Methotrexate?

Methotrexate may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Fatigue: persistent tiredness not related to activity level. - Mouth sores: ulceration of oral mucosa. - Low blood counts: reduced white cells, red cells or platelets.

Serious or Rare Side Effects: - Severe liver toxicity: elevated enzymes or hepatic failure. - Pulmonary fibrosis: progressive scarring of lung tissue. - Severe infection: opportunistic infections due to immunosuppression.

What precautions apply to Methotrexate?

Before initiating therapy, several safety considerations are recommended. - Monitor liver function: perform baseline and periodic liver enzyme tests. - Monitor blood counts: regular complete blood count to detect cytopenias. - Avoid use in pregnancy: drug is contraindicated and teratogenic. - Use effective contraception: both male and female patients must employ reliable methods. - Adjust dose in renal impairment: reduce dosage or increase monitoring as kidney function declines. - Store at below 25°C: keep in the original pack, protect from moisture.

What does Methotrexate interact with?

Methotrexate interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid): - NSAIDs: increase risk of renal toxicity and gastrointestinal ulceration. - Live vaccines: may cause uncontrolled infection due to immunosuppression. - Penicillins: can enhance methotrexate toxicity by reducing renal clearance.

Moderate Interactions (Monitor Closely): - Proton pump inhibitors: may increase methotrexate plasma levels. - Oral contraceptives: may reduce contraceptive effectiveness and require additional birth control measures.

Frequently asked questions

What conditions is Metotab used to treat?+
Metotab contains methotrexate, which is prescribed for rheumatoid arthritis, moderate to severe plaque psoriasis, certain hematologic cancers such as acute lymphoblastic leukemia and non‑Hodgkin lymphoma, and for medically managing ectopic pregnancy. The specific indication depends on the patient’s diagnosis and the prescribing physician’s assessment.
How does methotrexate work in the body?+
Methotrexate blocks the enzyme dihydrofolate reductase, halting the conversion of folate to its active form. This interruption stops the synthesis of nucleotides needed for DNA, RNA and protein production, leading to reduced proliferation of immune cells and cancer cells, which underlies its anti‑inflammatory and antineoplastic effects.
What is the usual dose of Metotab?+
The dose of Metotab is individualized by the treating physician based on the specific condition, disease severity, patient weight, renal function and other clinical factors. Only a qualified healthcare professional can determine the appropriate dosing regimen.
Is Metotab safe to use during pregnancy or breastfeeding?+
Methotrexate is classified as pregnancy category X because it is known to cause fetal malformations and embryotoxicity. It is contraindicated in pregnancy and women of childbearing potential must use reliable contraception. Use during breastfeeding is also discouraged, as the drug can be excreted in milk and affect the infant.
How do I order Metotab from GNH USA?+
To request Metotab, visit the product page on gnh-usa.com, enter the desired quantity, and submit the enquiry form. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Metotab compare with other disease‑modifying antirheumatic drugs?+
Compared with biologic DMARDs, methotrexate (Metotab) is an oral, small‑molecule agent that is generally less expensive and has a well‑established efficacy profile for rheumatoid arthritis and psoriasis. However, biologics may be preferred in patients who do not respond adequately to methotrexate or who have contraindications to its use.
What are the recommended storage conditions for Metotab?+
Metotab tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency throughout its shelf life.
How is Metotab administered?+
Metotab is taken orally, usually with water. Depending on the prescribing regimen, it may be taken once weekly or as directed by the physician. Patients should follow the specific instructions provided by their healthcare professional regarding timing, food intake and any necessary folic acid supplementation.
What are the most serious risks associated with Metotab?+
The most serious risks include severe liver toxicity, pulmonary fibrosis, bone marrow suppression leading to life‑threatening infections, and renal failure. Patients should be monitored regularly for liver enzymes, lung function, blood counts and kidney parameters to detect early signs of these complications.
Who should not use Metotab?+
Metotab is contraindicated in pregnant women, individuals with known hypersensitivity to methotrexate, patients with severe liver disease, uncontrolled infections, and those with significant renal impairment without dose adjustment. It should also be avoided in patients receiving live vaccines due to the risk of uncontrolled infection.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Methotrexate
Route
Oral Use
Manufacturer
Medac Gesellschaft Für Klinische Spezialpräparate Mbh (Wedel)
Origin
EU

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