Metoject Pen

Methotrexate, the active ingredient in Metoject Pen, is an antimetabolite (folate antagonist) presented as a pre‑filled subcutaneous pen injector for subcutaneous use. It is used to manage chronic inflammatory and autoimmune disorders, including rheumatoid arthritis, moderate to severe plaque psoriasis, and Crohn’s disease, primarily in adult patients. It is indicated for patients who have not responded adequately to conventional therapy.

GNH USA supplies Metoject Pen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory standards and is manufactured under GMP conditions.

Methotrexate is used as a disease‑modifying antirheumatic drug (DMARD) for several inflammatory conditions.

- Rheumatoid arthritis: reduces joint inflammation and slows disease progression. - Psoriasis: improves skin lesions and reduces plaque formation. - Crohn's disease: decreases intestinal inflammation and helps maintain remission.

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Fatigue: persistent tiredness. - Mouth sores: ulceration of oral mucosa. - Elevated liver enzymes: mild hepatic enzyme increase. - Headache: occasional mild headache. - Hair thinning: mild temporary loss of hair.

Serious or Rare Side Effects: - Severe liver toxicity: risk of hepatitis or fibrosis. - Bone marrow suppression: leading to anemia, leukopenia or thrombocytopenia. - Pulmonary fibrosis: interstitial lung disease. - Severe infection: opportunistic infections due to immunosuppression. - Kidney dysfunction: impaired renal function. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

When using Methotrexate, several precautions should be observed to minimize risks. - Monitor liver function: regular tests recommended. - Assess blood counts: watch for cytopenias. - Evaluate renal function: adjust if impaired. - Avoid use in pregnancy: teratogenic risk. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Methotrexate can interact with other medicines, affecting its safety and effectiveness.

Major Interactions (Avoid): - Live vaccines: may cause severe infection. - High-dose NSAIDs: increase methotrexate toxicity. - Other folate antagonists: additive toxicity.

Moderate Interactions (Monitor Closely): - Proton pump inhibitors: may affect renal clearance. - Sulfonamide antibiotics: risk of bone marrow suppression. - Alcohol: can exacerbate liver toxicity.