GNH USA

Europe — EMA

Metoject

GNH USA supplies Metoject (Methotrexate), a folate antagonist immunosuppressant for rheumatoid arthritis, psoriasis and certain cancers. Request a quote.

Methotrexate

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What is Methotrexate?

Methotrexate, the active ingredient in Metoject, is an antimetabolite (folate antagonist) presented as a subcutaneous formulation for injection use. It is employed to treat autoimmune disorders, certain malignancies and ectopic pregnancy in adult patients.

GNH USA supplies Metoject as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Methotrexate used for?

Methotrexate is used in several disease categories, primarily as an immunosuppressant and antineoplastic agent. - Rheumatoid arthritis: reduces joint inflammation and slows disease progression. - Psoriasis: decreases skin lesions and plaque formation. - Acute lymphoblastic leukemia: interferes with malignant cell proliferation. - Non‑Hodgkin lymphoma: contributes to tumor regression. - Ectopic pregnancy: terminates trophoblastic tissue growth.

What are the side effects of Methotrexate?

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea and vomiting. - Fatigue or malaise. - Mouth sores (stomatitis). - Elevated liver enzymes.

Serious or Rare Side Effects: - Severe liver toxicity or fibrosis. - Pulmonary fibrosis or interstitial pneumonitis. - Bone marrow suppression leading to pancytopenia.

What precautions apply to Methotrexate?

When using Methotrexate, careful monitoring and specific precautions are recommended to minimize risks. - Monitor liver function: perform regular liver enzyme tests. - Monitor blood counts: check complete blood count frequently. - Avoid use in pregnancy: contraindicated due to teratogenicity. - Use effective contraception: both male and female patients must use reliable methods. - Adjust dose in renal impairment: reduce dosage or increase monitoring. - Store at ambient temperature: keep in original packaging, protect from moisture.

What does Methotrexate interact with?

Methotrexate interacts with several medicines that can alter its efficacy or increase toxicity.

Major Interactions (Avoid): - NSAIDs: may increase methotrexate toxicity. - Trimethoprim: enhances myelosuppression. - Live vaccines: risk of severe infection.

Moderate Interactions (Monitor Closely): - Phenytoin: reduces methotrexate plasma levels. - Oral contraceptives: may decrease contraceptive effectiveness. - Azathioprine: additive immunosuppression risk.

Frequently asked questions

What conditions is Metoject used to treat?+
Metoject, containing methotrexate, is prescribed for several indications including rheumatoid arthritis, moderate to severe plaque psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, and ectopic pregnancy. In each case the drug works to suppress abnormal immune activity or to inhibit the growth of malignant cells.
How does methotrexate work in the body?+
Methotrexate blocks the enzyme dihydrofolate reductase, preventing the formation of tetrahydrofolate needed for DNA, RNA and protein synthesis. This limits the replication of rapidly dividing cells such as activated immune cells and cancer cells. Additionally, it raises extracellular adenosine, which contributes to its anti‑inflammatory properties.
What determines the dose of Metoject?+
The dose of Metoject is individualized by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and response to therapy. Dosage adjustments are made according to laboratory monitoring and clinical assessment, and patients should follow the prescriber’s instructions precisely.
Is Metoject safe during pregnancy or breastfeeding?+
Methotrexate is classified as pregnancy category X because it is known to cause fetal malformations and embryotoxicity. It is contraindicated in pregnancy and women of child‑bearing potential must use effective contraception. Limited data exist for breastfeeding, and the drug is generally avoided due to potential infant exposure.
How do I order Metoject from GNH USA?+
To order Metoject, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.
How does Metoject compare with other disease‑modifying antirheumatic drugs?+
Compared with biologic DMARDs, methotrexate (Metoject) is a small‑molecule agent that is generally less expensive and administered by subcutaneous injection. It has a well‑established efficacy profile for rheumatoid arthritis and psoriasis, but may require more laboratory monitoring for hepatic and hematologic toxicity.
What are the recommended storage conditions for Metoject?+
Metoject should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight. Do not freeze the preparation, and keep it out of reach of children.
How is Metoject administered to patients?+
Metoject is given by subcutaneous injection, typically into the abdomen or thigh. The injection site should be rotated to reduce local irritation. Administration is performed by a healthcare professional or a trained patient following aseptic technique and the prescriber’s dosing schedule.
What are the most serious risks associated with Metoject?+
The most serious risks include severe liver toxicity or fibrosis, pulmonary fibrosis or interstitial pneumonitis, and bone‑marrow suppression that can lead to pancytopenia. These events are rare but require prompt medical attention and regular monitoring of liver function, lung status and blood counts.
Who should not use Metoject?+
Metoject is contraindicated in pregnant women, patients with severe renal or hepatic impairment, and individuals with known hypersensitivity to methotrexate. It should also be avoided in patients receiving live vaccines or those with uncontrolled infections, unless the prescriber determines the benefits outweigh the risks.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Methotrexate
Route
Subcutaneous Use
Manufacturer
Medac Gesellschaft Für Klinische Spezialpräparate Mbh (Wedel)
Origin
EU

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