GNH USA

Europe — EMA

Metoject

GNH USA supplies Metoject (Methotrexate), an antimetabolite for rheumatoid arthritis, psoriasis, leukemia and lymphoma. Request a quote for global supply.

Methotrexate

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What is Methotrexate?

Methotrexate, the active ingredient in Metoject, is an antimetabolite presented as a solution for injection for intramuscular, intravenous, subcutaneous use. It treats rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma and gestational trophoblastic disease.

GNH USA supplies Metoject as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

What is Methotrexate used for?

Methotrexate is used in several autoimmune and oncologic conditions that involve rapid cell proliferation.

Rheumatoid arthritis: reduces joint inflammation and slows disease progression. Psoriasis: limits skin cell overgrowth and improves plaque appearance. Acute lymphoblastic leukemia: interferes with malignant lymphoblast replication. Non‑Hodgkin lymphoma: hampers growth of lymphoma cells. Gestational trophoblastic disease: induces remission by targeting trophoblastic tissue.

What are the side effects of Methotrexate?

Methotrexate may cause a range of adverse reactions.

Common Side Effects: - Nausea or vomiting. - Fatigue or malaise. - Oral mucositis (mouth sores). - Transient elevation of liver enzymes. - Mild rash or itching. - Decreased white blood cell count.

Serious or Rare Side Effects: - Severe hepatotoxicity or liver failure. - Pulmonary fibrosis or interstitial pneumonitis. - Life‑threatening infection due to bone‑marrow suppression. - Acute renal failure. - Anaphylactic or severe hypersensitivity reactions. - Significant pancytopenia.

What precautions apply to Methotrexate?

Methotrexate requires careful monitoring and specific safety measures. - Pregnancy: contraindicated (Category X); avoid in women of childbearing potential. - Renal function: assess creatinine clearance before initiation and periodically. - Liver function: monitor transaminases and bilirubin regularly. - Hematology: perform baseline and periodic complete blood counts. - Concomitant NSAIDs: avoid high‑dose NSAIDs due to increased renal toxicity risk. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

What does Methotrexate interact with?

Methotrexate interacts with several drug classes that may alter its safety profile.

Major Interactions (Avoid): - NSAIDs (high dose): increase risk of renal toxicity. - Live vaccines: heightened risk of infection. - Trimethoprim‑sulfamethoxazole: additive bone‑marrow suppression.

Moderate Interactions (Monitor Closely): - Azathioprine: enhanced myelosuppression. - Proton pump inhibitors: may affect renal clearance. - Alcohol: potentiates hepatotoxicity.

Frequently asked questions

What conditions is Metoject used to treat?+
Metoject contains methotrexate and is indicated for rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma and gestational trophoblastic disease. In each condition the drug works by limiting the rapid proliferation of immune or malignant cells.
How does methotrexate work in the body?+
Methotrexate blocks the enzyme dihydrofolate reductase, reducing tetrahydrofolate needed for DNA and RNA synthesis. This inhibition curtails cell division, particularly affecting fast‑growing immune cells in autoimmune disease and cancer cells in hematologic malignancies.
What is the usual dose of Metoject?+
The specific dose of Metoject is determined by the prescribing clinician based on the patient’s condition, weight, renal and hepatic function, and treatment goals. Dosing regimens vary widely across the different approved indications.
Is Metoject safe during pregnancy or breastfeeding?+
Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal malformations and miscarriage. It is also excreted in breast milk, so breastfeeding is not recommended while receiving the drug.
How do I order Metoject from GNH USA?+
To request Metoject, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.
How does Metoject compare with other antimetabolites?+
Compared with other antimetabolites such as azathioprine or cytarabine, methotrexate has a broader range of approved indications, including both autoimmune disorders and several cancers. Its dosing flexibility (intramuscular, intravenous, subcutaneous) and well‑characterized safety profile make it a frequently chosen option, though monitoring requirements are similar across the class.
What are the storage and handling requirements for Metoject?+
Metoject should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.
How is Metoject administered to patients?+
Metoject is supplied as a sterile solution for injection and can be given intramuscularly, intravenously or subcutaneously by a qualified healthcare professional. The route and rate of administration are selected by the prescriber according to the specific indication and patient factors.
What are the most serious risks associated with Metoject?+
The most serious risks include severe liver toxicity, pulmonary fibrosis, life‑threatening infections due to bone‑marrow suppression, renal failure, and rare anaphylactic reactions. Patients should be monitored regularly for liver enzymes, lung function, renal parameters and complete blood counts.
Who should not use Metoject?+
Metoject is contraindicated in pregnant women, individuals with severe hepatic or renal impairment, patients with known hypersensitivity to methotrexate or any excipients, and those receiving live vaccines. Caution is also advised for patients with pre‑existing blood disorders or uncontrolled infections.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Methotrexate
Route
Intramuscular Use , Intravenous Use , Subcutaneous
Manufacturer
Medac Gesellschaft Für Klinische Spezialpräparate Mbh (Wedel)
Origin
EU

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