GNH USA

Europe — EMA

Metoject

GNH USA supplies Metoject (Methotrexate), an antimetabolite for rheumatoid arthritis, psoriasis and certain cancers. Request a quote for global supply.

Methotrexate

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What is Methotrexate?

Methotrexate, the active ingredient in Metoject, is an antimetabolite presented as an injectable solution for intramuscular, intravenous, and subcutaneous use. It is employed to treat autoimmune disorders such as rheumatoid arthritis and psoriasis, as well as certain cancers including acute lymphoblastic leukemia and non‑Hodgkin lymphoma. It is also indicated for gestational trophoblastic disease.

GNH USA supplies Metoject as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies, and clinics worldwide, ensuring quality and regulatory compliance across all markets.

What is Methotrexate used for?

Methotrexate is used in autoimmune and oncologic conditions where it modulates cell proliferation and immune response.

Rheumatoid arthritis: reduces joint inflammation and slows disease progression. Psoriasis: diminishes skin plaque formation and severity. Acute lymphoblastic leukemia: interferes with malignant cell replication. Non‑Hodgkin lymphoma: inhibits growth of lymphoma cells. Gestational trophoblastic disease: promotes resolution of trophoblastic tissue.

What are the side effects of Methotrexate?

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Fatigue - Mouth sores - Low white blood cell count

Serious or Rare Side Effects: - Severe bone marrow suppression - Pulmonary fibrosis - Hepatotoxicity leading to cirrhosis

What precautions apply to Methotrexate?

Use of Metoject requires careful monitoring and adherence to safety guidelines. - Pregnancy: contraindicated (Category X) due to teratogenic risk. - Renal function: assess before initiation and monitor regularly. - Liver function: monitor transaminases; avoid in severe hepatic impairment. - Hematologic monitoring: perform complete blood counts frequently. - Drug interactions: avoid concurrent use with NSAIDs that may increase toxicity. - Store at ambient temperature: keep in original container, protect from light and moisture.

What does Methotrexate interact with?

Methotrexate interacts with several medicines; some combinations must be avoided while others need close observation.

Major Interactions (Avoid): - Live vaccines: may cause severe infection. - High-dose NSAIDs: increase risk of renal toxicity. - Sulfonamide antibiotics: may enhance myelosuppression.

Moderate Interactions (Monitor Closely): - Proton pump inhibitors: may affect absorption. - Trimethoprim‑sulfamethoxazole: additive bone marrow suppression. - Phenytoin: may reduce methotrexate levels.

Frequently asked questions

What is Metoject used for?+
Metoject contains methotrexate, which is prescribed for several conditions including rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, and gestational trophoblastic disease. It works by suppressing abnormal immune activity and inhibiting the growth of rapidly dividing cancer cells.
How does methotrexate work?+
Methotrexate blocks the enzyme dihydrofolate reductase, preventing the formation of tetrahydrofolate needed for DNA, RNA and protein synthesis. This limits the proliferation of rapidly dividing cells such as immune cells and malignant tumor cells, providing both immunosuppressive and antineoplastic effects.
What determines the dose of Metoject?+
The dose of Metoject is individualized by the prescribing clinician based on the specific indication, disease severity, patient weight, renal and hepatic function, and response to therapy. Only a qualified health professional should set the dosing regimen.
Is Metoject safe during pregnancy or breastfeeding?+
Metoject is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal malformations and death. It is also not recommended while breastfeeding, as methotrexate can be excreted in breast milk and may harm the infant.
How do I order Metoject from GNH USA?+
To order Metoject, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Metoject compare with the main alternative drug or class?+
Metoject (methotrexate) is an antimetabolite, whereas many alternatives for rheumatoid arthritis are biologic agents such as TNF‑alpha inhibitors. Methotrexate is generally less expensive and administered orally or by injection, but biologics may offer faster symptom control for patients who do not respond adequately to methotrexate.
How should Metoject be stored and handled?+
Metoject should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from light, moisture and extreme temperatures. Do not freeze. Follow standard aseptic techniques when preparing the injectable solution for administration.
How is Metoject administered?+
Metoject is supplied as an injectable solution and can be given by intramuscular, intravenous, or subcutaneous injection. The route, site and frequency are determined by the prescribing clinician and should be performed by a qualified health‑care professional following aseptic procedures.
What are the most serious risks to watch for with Metoject?+
Serious risks include severe bone marrow suppression leading to pancytopenia, hepatotoxicity that can progress to cirrhosis, and pulmonary fibrosis. Patients should be monitored regularly for blood counts, liver function tests and respiratory symptoms, and therapy should be stopped if any of these severe reactions occur.
Who should not use Metoject?+
Metoject should not be used by pregnant women, individuals with severe renal or hepatic impairment, patients with pre‑existing bone marrow disorders, or those receiving live vaccines. It is also contraindicated in patients with known hypersensitivity to methotrexate or any component of the formulation.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Methotrexate
Route
Intramuscular Use , Intravenous Use , Subcutaneous
Manufacturer
Medac Gesellschaft Für Klinische Spezialpräparate Mbh (Wedel)
Origin
EU

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