GNH USA

Europe — EMA

Metoject

GNH USA supplies Metoject (Methotrexate), a folate antagonist for rheumatoid arthritis, psoriasis, and certain cancers. Request a quote for global supply.

Methotrexate

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1
Pack/s

What is Methotrexate?

Methotrexate, the active ingredient in Metoject, is a folate antagonist (antimetabolite) presented as an injectable solution for intramuscular, intravenous, and subcutaneous use. It is employed to treat autoimmune disorders and certain malignancies in adult and pediatric patients.

GNH USA supplies Metoject as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory documentation for import and distribution. Customers benefit from reliable supply chains and responsive technical support throughout the product lifecycle.

What is Methotrexate used for?

Methotrexate acts as a folate pathway inhibitor and is indicated for several autoimmune and oncologic conditions.

Rheumatoid arthritis: reduces joint inflammation and slows disease progression. Psoriasis: improves skin lesions and decreases plaque formation. Acute lymphoblastic leukemia: induces remission by inhibiting malignant cell proliferation. Non‑Hodgkin lymphoma: contributes to tumor control in combination regimens. Gestational trophoblastic disease: promotes resolution of trophoblastic tissue.

What are the side effects of Methotrexate?

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Fatigue - Mouth sores - Elevated liver enzymes

Serious or Rare Side Effects: - Severe liver toxicity - Pulmonary fibrosis - Bone marrow suppression

What precautions apply to Methotrexate?

When using Metoject, several safety measures should be observed.

Monitor liver function: perform baseline and periodic liver enzyme tests. Assess blood counts: regular CBC to detect cytopenias. Avoid in pregnancy: contraindicated due to teratogenicity. Use folic acid supplementation: reduces mucosal toxicity. Adjust dose in renal impairment: evaluate renal function before each administration. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Methotrexate interact with?

Methotrexate has notable drug interactions that require attention.

Major Interactions (Avoid): - NSAIDs: increase methotrexate toxicity. - Live vaccines: heightened risk of infection. - Penicillins: enhance myelosuppression. - Sulfonamides: increase hematologic toxicity.

Moderate Interactions (Monitor Closely): - Warfarin: enhanced anticoagulant effect. - Proton pump inhibitors: may alter absorption. - Trimethoprim: additive bone marrow suppression.

Frequently asked questions

What is Metoject used for?+
Metoject contains methotrexate and is prescribed for several conditions, including rheumatoid arthritis, severe plaque psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, and gestational trophoblastic disease. In each case the drug works to suppress abnormal immune activity or malignant cell growth.
How does methotrexate work?+
Methotrexate blocks the enzyme dihydrofolate reductase, which is essential for converting folate into its active form. This interruption stops the synthesis of DNA, RNA and proteins, thereby reducing the proliferation of rapidly dividing cells such as activated immune cells and cancerous lymphocytes.
What is the usual dose of Metoject?+
The dose of Metoject is individualized. A qualified prescriber determines the amount, frequency and route based on the specific indication, patient weight, renal function and other clinical factors. No standard dosing can be quoted without a medical prescription.
Is Metoject safe during pregnancy or breastfeeding?+
Metoject is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal malformations or death. It is also not recommended while breastfeeding, as methotrexate can be excreted in milk and affect the infant.
How do I order Metoject from GNH USA?+
To request Metoject, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Metoject compare with other treatments?+
Compared with biologic agents used for rheumatoid arthritis or psoriasis, methotrexate is a small‑molecule drug that can be administered by injection and is generally less expensive. However, biologics may have a more targeted mechanism and a different safety profile, while methotrexate offers broad immunosuppressive activity useful in both autoimmune and oncologic settings.
How should Metoject be stored and handled?+
Metoject should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or particulate.
How is Metoject administered?+
Metoject is supplied as an injectable solution and can be given intramuscularly, intravenously or subcutaneously, depending on the clinical indication and prescriber preference. Administration is performed by a qualified healthcare professional using aseptic technique.
What are the most serious risks to watch for?+
The most critical adverse events include severe liver toxicity, pulmonary fibrosis, and bone‑marrow suppression leading to pancytopenia. Patients should be monitored regularly for liver enzyme elevations, respiratory symptoms and blood‑count abnormalities, and treatment should be stopped if any of these serious reactions occur.
Who should not use Metoject?+
Metoject is contraindicated in pregnant women, individuals with known hypersensitivity to methotrexate, patients with severe hepatic or renal impairment, and those with active, uncontrolled infections. Caution is also advised for patients with pre‑existing lung disease or immunodeficiency.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Methotrexate
Route
Intramuscular Use , Intravenous Use , Subcutaneous
Manufacturer
Medac Gesellschaft Für Klinische Spezialpräparate Mbh (Wedel)
Origin
EU

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