GNH USA

Europe — EMA

Metoclopramida Labesfal (Metoclopramide Hydrochloride Monohydrate)

GNH USA supplies Metoclopramida Labesfal (Metoclopramide), a dopamine D2 receptor antagonist for nausea, vomiting and gastroparesis.

Metoclopramide Hydrochloride Monohydrate

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What is Metoclopramide Hydrochloride Monohydrate?

Metoclopramide, the active ingredient in Metoclopramida Labesfal, is a dopamine D2 receptor antagonist presented as an oral dosage form for oral use. It is employed to treat nausea, vomiting, gastroparesis and related gastrointestinal motility disorders in adult patients.

GNH USA supplies Metoclopramida Labesfal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metoclopramide Hydrochloride Monohydrate used for?

Metoclopramide acts on the dopaminergic and serotonergic pathways to control emesis and improve gastrointestinal motility. - Nausea and vomiting: reduces the frequency and severity of acute and chemotherapy‑induced episodes. - Gastroparesis: enhances gastric emptying and alleviates associated symptoms. - Gastroesophageal reflux disease: improves lower esophageal sphincter tone and reduces reflux episodes.

What are the side effects of Metoclopramide Hydrochloride Monohydrate?

Metoclopramide may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Drowsiness: transient sleepiness or fatigue. - Restlessness: feelings of inner tension or akathisia. - Diarrhea: loose stools or increased bowel movements. - Headache: mild to moderate cranial pain.

Serious or Rare Side Effects: - Extrapyramidal reactions: muscle rigidity, tremor, or dystonia. - Tardive dyskinesia: persistent involuntary movements after prolonged use. - Neuroleptic malignant syndrome: life‑threatening hyperthermia and muscle breakdown.

What precautions apply to Metoclopramide Hydrochloride Monohydrate?

Metoclopramide requires careful use in several clinical situations. - Contraindicated in patients with bowel obstruction: risk of perforation. - Caution in renal impairment: reduced clearance may increase toxicity. - Monitor for extrapyramidal symptoms: early detection prevents progression. - Avoid in known hypersensitivity to metoclopramide or its excipients. - Use with caution in the elderly: heightened central nervous system effects. - Store at room temperature: keep in the original pack, protect from moisture.

What does Metoclopramide Hydrochloride Monohydrate interact with?

Metoclopramide can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Antipsychotics (e.g., haloperidol): additive dopamine blockade may increase extrapyramidal risk. - MAO inhibitors: combined serotonergic activity can precipitate serotonin syndrome. - CNS depressants (e.g., benzodiazepines): enhanced sedation and respiratory depression.

Moderate Interactions (Monitor Closely): - Opioids: may augment gastrointestinal side effects. - Antihistamines: increased drowsiness. - SSRIs and SNRIs: potential for additive serotonergic effects. - Anticholinergics: may reduce pro‑kinetic benefit.

Frequently asked questions

What conditions is Metoclopramida Labesfal used for?+
Metoclopramida Labesfal contains metoclopramide, which is prescribed to manage nausea and vomiting, treat gastroparesis by enhancing gastric emptying, and alleviate symptoms of gastroesophageal reflux disease through its pro‑kinetic and anti‑emetic actions.
How does metoclopramide work in the body?+
Metoclopramide blocks dopamine D2 receptors in the chemoreceptor trigger zone, antagonizes 5‑HT3 receptors, and stimulates 5‑HT4 receptors. This combination suppresses central vomiting signals while increasing acetylcholine release, which promotes coordinated gastrointestinal motility.
What is the usual dose of Metoclopramida Labesfal?+
The appropriate dose of Metoclopramida Labesfal is determined by the prescribing clinician based on the patient’s condition, age, renal function and other individual factors. Dosage regimens are not standardized and should follow the prescriber’s instructions.
Is Metoclopramida Labesfal safe during pregnancy or breastfeeding?+
Safety data for metoclopramide in pregnancy are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies any possible risk to the fetus. Breastfeeding mothers should consult a healthcare professional before use.
How do I order Metoclopramida Labesfal from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does metoclopramide compare with other anti‑emetic drugs?+
Metoclopramide differs from many anti‑emetics by combining dopamine antagonism with serotonergic activity and a pro‑kinetic effect. Unlike pure 5‑HT3 antagonists such as ondansetron, it also enhances gastric motility, making it useful for conditions like gastroparesis, but it carries a higher risk of extrapyramidal side effects.
What are the recommended storage conditions for Metoclopramida Labesfal?+
Metoclopramida Labesfal should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. No refrigeration is required for this oral formulation.
How is Metoclopramida Labesfal administered?+
The product is taken orally, usually with or without food, as directed by a healthcare professional. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.
What are the most serious risks associated with metoclopramide?+
Serious risks include extrapyramidal reactions such as acute dystonia, tardive dyskinesia with long‑term use, and rare occurrences of neuroleptic malignant syndrome. Patients should be monitored for muscle rigidity, involuntary movements, fever or altered mental status and seek immediate medical attention if these arise.
Who should not use Metoclopramida Labesfal?+
Metoclopramida Labesfal is contraindicated in individuals with known hypersensitivity to metoclopramide, those with gastrointestinal obstruction, perforation or hemorrhage, and patients with pheochromocytoma. Caution is also advised for patients with severe depression or seizure disorders.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metoclopramide Hydrochloride Monohydrate
Route
Oral Use
Manufacturer
Generis Farmacêutica, S.A.
Origin
EU

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