Metida

Dimetindene Maleate, the active ingredient in Metida, is a first‑generation antihistamine presented as a topical formulation for skin application. It blocks peripheral H1 receptors, reducing histamine‑mediated vasodilation, edema and itching in patients with allergic skin conditions such as atopic dermatitis, urticaria and insect bite reactions.

GNH USA supplies Metida as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable global distribution.

Metida, a topical antihistamine, is used to manage pruritic and allergic skin conditions.

- Pruritus due to allergic skin conditions: reduces itching and discomfort. - Atopic dermatitis: helps control flare‑ups and associated itch. - Insect bite reactions: relieves localized swelling and itching. - Urticaria: provides rapid relief of hive‑related itching.

Topical application of Dimetindene Maleate may be associated with local and systemic adverse reactions.

Common Side Effects: - Skin irritation: mild redness or burning at the application site. - Pruritus worsening: transient increase in itching. - Dryness: localized skin dryness.

Serious or Rare Side Effects: - Allergic contact dermatitis: severe rash or swelling. - Angioedema: rapid swelling of deeper skin layers. - Systemic hypersensitivity: urticaria or anaphylactoid reaction.

When using Metida, certain precautions should be observed to ensure safety and effectiveness.

- Age restriction: avoid use in children under 2 years unless directed by a physician. - Application area: limit to affected skin; avoid eyes, mucous membranes and broken skin. - Concomitant medications: do not combine with other topical antihistamines without professional advice. - Pregnancy and lactation: safety not established; use only if benefits outweigh risks. - Systemic absorption: monitor for signs of systemic antihistamine effects in extensive use. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Dimetindene Maleate may interact with certain systemic agents and topical products.

Major Interactions (Avoid): - Potent CYP450 inhibitors: may increase systemic exposure if large skin areas are treated. - Other H1 antagonists: additive sedative or anticholinergic effects when absorbed.

Moderate Interactions (Monitor Closely): - Topical corticosteroids: may alter skin barrier and affect drug absorption. - Alcohol‑containing skin products: can increase irritation risk. - Systemic antihistamines: monitor for cumulative antihistaminic effect.