GNH USA

Europe — EMA

Metibasol

GNH USA supplies Metibasol (Thiamazole), an antithyroid agent for hyperthyroidism and toxic nodular goiter. Request a quote for global supply today.

Thiamazole

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What is Thiamazole?

Thiamazole, the active ingredient in Metibasol, is an antithyroid agent presented as a tablet for oral use. It treats hyperthyroidism, such as Graves disease, in adults.

GNH USA supplies Metibasol as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Thiamazole used for?

Metibasol is an antithyroid medication used to manage conditions characterized by excess thyroid hormone production.

Hyperthyroidism: reduces overproduction of thyroid hormones and alleviates associated symptoms. Graves disease: controls the autoimmune stimulation of the thyroid gland. Toxic nodular goiter: lowers hormone synthesis in autonomously functioning thyroid nodules.

What are the side effects of Thiamazole?

Metibasol may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea or upset stomach - Skin rash or itching - Altered taste sensation - Joint or muscle aches - Headache - Mild elevation of liver enzymes

Serious or Rare Side Effects: - Agranulocytosis (dangerously low white blood cell count) - Severe liver injury or hepatitis - Vasculitis affecting small blood vessels - Acute pancreatitis - Myocarditis or pericarditis

What precautions apply to Thiamazole?

Before initiating Metibasol therapy, several safety considerations should be observed.

Monitor blood counts: perform regular complete blood count tests to detect early neutropenia. Assess liver function: periodic liver enzyme monitoring is recommended. Avoid in known hypersensitivity: discontinue if severe rash or allergic reaction occurs. Caution in elderly patients: dose may require adjustment due to altered metabolism. Pregnancy considerations: discuss potential risks and benefits with a healthcare professional. Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

What does Thiamazole interact with?

Metibasol can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid): - Lithium: combined use may increase risk of thyroid dysfunction. - Warfarin: thiamazole can potentiate anticoagulant effect, raising bleeding risk. - Interferon‑alpha: may exacerbate thyroid abnormalities.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may mask symptoms of thyrotoxicosis. - Iodine‑containing contrast agents: can reduce antithyroid effectiveness. - Oral contraceptives: thiamazole may diminish contraceptive efficacy. - Cholestyramine or other bile‑acid sequestrants: may lower thiamazole absorption.

Frequently asked questions

What is Metibasol used for?+
Metibasol contains thiamazole, an antithyroid agent prescribed to lower excess thyroid hormone production. It is indicated for conditions such as hyperthyroidism, Graves disease, and toxic nodular goiter, helping to control symptoms like rapid heart rate, weight loss, and tremor.
How does thiamazole work?+
Thiamazole blocks the enzyme thyroid peroxidase, which is essential for adding iodine to tyrosine residues and coupling them to form thyroxine (T4) and triiodothyronine (T3). By inhibiting this step, the drug reduces the synthesis of active thyroid hormones and mitigates the hyperactive thyroid state.
What is the usual dose of Metibasol?+
The appropriate dose of Metibasol is individualized by a qualified prescriber based on the severity of the thyroid condition, patient age, weight, and response to therapy. Dosage regimens can vary, and any adjustments should be made under medical supervision.
Is Metibasol safe during pregnancy or breastfeeding?+
Safety data for thiamazole in pregnancy and lactation are limited. Use during pregnancy is generally reserved for situations where the benefits outweigh potential risks, and it should be avoided in the first trimester if possible. Breastfeeding mothers should consult their physician before using Metibasol.
How do I order Metibasol from GNH USA?+
To request Metibasol, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Metibasol compare with the main alternative drug?+
The primary alternative to thiamazole is propylthiouracil (PTU). Both inhibit thyroid hormone synthesis, but PTU also blocks peripheral conversion of T4 to T3. Thiamazole is generally preferred for long‑term management because of a more favorable safety profile, whereas PTU is reserved for specific situations such as the first trimester of pregnancy.
How should Metibasol be stored and handled?+
Metibasol tablets should be stored at room temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or direct sunlight.
How is Metibasol administered?+
Metibasol is taken orally, usually with a glass of water. It can be taken with or without food, but consistency with meals may help reduce gastrointestinal discomfort. Patients should follow the prescriber’s instructions regarding timing and whether the dose should be split throughout the day.
What are the most serious risks to watch for while taking Metibasol?+
The most critical adverse events include agranulocytosis, a severe drop in white blood cells that can lead to infection, and serious liver injury such as hepatitis. Patients should promptly report fever, sore throat, jaundice, dark urine, or unexplained fatigue to their healthcare provider.
Who should not use Metibasol?+
Metibasol is contraindicated in individuals with known hypersensitivity to thiamazole or any thioamide compounds. It should be used with caution, or avoided, in patients with severe liver disease, existing bone marrow suppression, or those who are pregnant during the first trimester unless no safer alternative exists.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Thiamazole
Route
Oral Use
Manufacturer
Sanóbia-Centro De Saúde E Estética, Limitada
Origin
EU

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