Methotrexate Arrow

Methotrexate, the active ingredient in Methotrexate Arrow, is a folate antagonist antimetabolite presented as an oral tablet for oral use. It is used to treat rheumatoid arthritis, psoriasis, and certain cancers in adult patients.

GNH USA supplies Methotrexate Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Methotrexate acts on rapidly dividing cells and modulates immune pathways, making it useful in several disease families.

Rheumatoid arthritis: reduces joint inflammation and slows disease progression. Psoriasis: decreases skin cell proliferation and improves lesions. Acute lymphoblastic leukemia, osteosarcoma, gestational trophoblastic disease: interferes with cancer cell replication, contributing to tumor control.

Methotrexate may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Nausea or vomiting. - Fatigue or malaise. - Mouth sores (stomatitis). - Mild elevation of liver enzymes. - Decreased white blood cell count. - Diarrhea.

Serious or Rare Side Effects: - Severe liver toxicity or hepatitis. - Pulmonary fibrosis or severe lung inflammation. - Significant bone marrow suppression leading to anemia or infection. - Renal failure or impaired kidney function. - Life‑threatening skin reactions such as Stevens‑Johnson syndrome. - Severe infections due to immunosuppression.

Before initiating therapy, several safety measures should be considered.

Monitor blood counts: perform regular complete blood count testing. Assess liver function: check hepatic enzymes periodically. Avoid in pregnancy: methotrexate is contraindicated (Category X). Check renal function: evaluate creatinine and glomerular filtration rate. Review concomitant nephrotoxic drugs: adjust therapy as needed. Store at ambient temperature: keep in the original container, protect from moisture and heat.

Methotrexate interacts with several medicines that can alter its efficacy or toxicity.

Major Interactions (Avoid): - NSAIDs (e.g., ibuprofen, naproxen): increase methotrexate toxicity. - Penicillins (e.g., ampicillin): reduce renal clearance, raising plasma levels. - Proton pump inhibitors (e.g., omeprazole): may elevate methotrexate concentrations.

Moderate Interactions (Monitor Closely): - Sulfonamides: additive bone‑marrow suppression risk. - Live vaccines: heightened infection risk due to immunosuppression. - Alcohol: amplifies liver injury potential.