Methergin

Methylergometrine maleate, the active ingredient in Methergin, is an ergot alkaloid presented as an injectable solution for intramuscular and intravenous use. It is used to prevent and treat postpartum hemorrhage and uterine atony in women after delivery.

GNH USA supplies Methergin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Methylergometrine maleate is an ergot alkaloid uterotonic used to manage uterine bleeding.

- Postpartum hemorrhage: helps control excessive bleeding by stimulating strong uterine contractions. - Uterine atony: restores tone to a relaxed uterus following childbirth. - Prophylaxis of postpartum hemorrhage: administered after delivery to reduce the risk of severe bleeding.

Methylergometrine maleate may cause a range of adverse reactions.

Common Side Effects: - Nausea - Vomiting - Headache - Hypertension - Abdominal pain - Flushing

Serious or Rare Side Effects: - Coronary artery spasm or myocardial infarction - Severe hypertension or hypertensive crisis - Seizures - Allergic reactions including anaphylaxis - Uterine rupture - Peripheral ischemia

Methylergometrine maleate requires careful clinical assessment before use.

- Contraindication in pregnancy: not to be used before delivery due to fetal toxicity. - Hypertension: monitor blood pressure closely as the drug can raise systemic pressure. - Cardiovascular disease: avoid in patients with coronary artery disease or severe vascular disorders. - Asthma: use with caution because bronchospasm may occur. - Drug hypersensitivity: discontinue immediately if an allergic reaction is observed. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Methylergometrine maleate can interact with several medication classes.

Major Interactions (Avoid): - Other ergot derivatives: additive vasoconstriction risk. - MAO inhibitors: may precipitate hypertensive crisis. - Strong CYP3A4 inhibitors (e.g., ketoconazole): increase plasma concentrations. - Concomitant vasopressors (e.g., norepinephrine): severe hypertension.

Moderate Interactions (Monitor Closely): - Calcium channel blockers: may enhance uterine contractile effect. - SSRIs or other serotonergic agents: potential serotonin syndrome. - Lithium: increased risk of toxicity.