Metformine Teva

Metformin, the active ingredient in Metformine Teva, is a biguanide presented as a tablet for oral use. It treats type 2 diabetes mellitus in adults by improving blood‑glucose control. GNH USA supplies Metformine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metformine Teva is an oral antidiabetic that acts on glucose metabolism in patients with insulin resistance. - Type 2 diabetes mellitus: improves glycaemic control and reduces fasting plasma glucose. - Polycystic ovary syndrome: helps restore ovulatory cycles by decreasing insulin resistance. - Impaired glucose tolerance (prediabetes): delays progression to overt diabetes when used under medical supervision.

Metformine Teva may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Gastrointestinal upset: nausea, abdominal discomfort, or loss of appetite. - Diarrhoea: frequent loose stools, especially during treatment initiation. - Metallic taste: transient alteration in taste perception. - Flatulence: increased intestinal gas. - Weight loss: modest reduction in body weight.

Serious or Rare Side Effects: - Lactic acidosis: a rare but life‑threatening accumulation of lactate. - Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatic failure: rare liver injury in susceptible individuals. - Vitamin B12 deficiency: may develop with long‑term therapy. - Pancreatitis: inflammation of the pancreas reported infrequently.

Metformine Teva requires careful monitoring and specific safety measures. - Renal function: assess eGFR before starting and monitor periodically; avoid if severe renal impairment exists. - Hepatic function: contraindicated in patients with significant liver disease due to lactic acidosis risk. - Lactic acidosis risk: discontinue in conditions predisposing to hypoxia (e.g., heart failure, severe infection). - Pregnancy and lactation: use only if clearly needed and prescribed by a healthcare professional. - Vitamin B12 monitoring: consider periodic assessment during long‑term therapy. - Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture and direct sunlight.

Metformine Teva can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Iodinated contrast agents: may precipitate acute renal failure and lactic acidosis. - Cimetidine: can increase metformin plasma concentrations. - Certain antiretrovirals (e.g., didanosine, stavudine): raise risk of lactic acidosis. - Alcohol excess: enhances risk of hypoglycaemia and lactic acidosis. - High‑dose diuretics: may impair renal clearance of metformin.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may mask hypoglycaemic symptoms. - ACE inhibitors or ARBs: monitor renal function and electrolytes. - NSAIDs: can reduce renal perfusion, affecting metformin elimination. - Oral contraceptives: may modestly increase plasma metformin levels. - Corticosteroids: may raise blood glucose, requiring dose adjustments.