GNH USA

Europe — EMA

Metformina + Sitagliptina Zentiva K.S.

GNH USA supplies Metformina + Sitagliptina Zentiva K.S. (Metformin hydrochloride and sitagliptin), a biguanide and DPP‑4 inhibitor for type 2 diabetes

Metformin Hydrochloride, Sitagliptin

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What is Metformin Hydrochloride, Sitagliptin?

Metformin hydrochloride and sitagliptin, the active ingredient in Metformina + Sitagliptina Zentiva K.S., is a biguanide and DPP‑4 inhibitor presented as a tablet for oral use. It is indicated for the management of type 2 diabetes mellitus in adults.

GNH USA supplies Metformina + Sitagliptina Zentiva K.S. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metformin Hydrochloride, Sitagliptin used for?

Metformina + Sitagliptina Zentiva K.S. is used in the treatment of type 2 diabetes mellitus, targeting glucose regulation.

- Type 2 diabetes mellitus (adult): improves overall glycemic control when combined with diet and exercise. - Type 2 diabetes mellitus (adult): reduces fasting plasma glucose levels. - Type 2 diabetes mellitus (adult): lowers HbA1c by an additional 0.5–1.0% when added to metformin alone.

What are the side effects of Metformin Hydrochloride, Sitagliptin?

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Diarrhea: frequent loose stools, usually transient. - Abdominal discomfort: cramping or pain. - Metallic taste: altered taste perception. - Headache: mild tension‑type headache. - Decreased appetite: reduced hunger sensations.

Serious or Rare Side Effects: - Lactic acidosis: rare but potentially fatal metabolic disturbance. - Severe hypoglycemia: especially when combined with insulin or sulfonylureas. - Pancreatitis: acute inflammation of the pancreas. - Severe skin reactions: such as Stevens‑Johnson syndrome. - Hepatic failure: marked liver enzyme elevation. - Anaphylaxis: rare allergic reaction requiring immediate medical attention.

What precautions apply to Metformin Hydrochloride, Sitagliptin?

Before initiating therapy, consider the following precautions: - Renal function: assess eGFR and avoid use in severe renal impairment. - Hepatic impairment: avoid in patients with significant liver disease due to lactic acidosis risk. - Hypoglycemia risk: monitor closely when used with insulin or sulfonylureas. - Pregnancy: prescribe only if potential benefits justify potential risks. - Vitamin B12 monitoring: long‑term metformin may reduce B12 absorption. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

What does Metformin Hydrochloride, Sitagliptin interact with?

Metformina + Sitagliptina Zentiva K.S. may interact with several medicines:

Major Interactions (Avoid): - Insulin or sulfonylureas: increased risk of severe hypoglycemia. - Iodinated contrast agents: may precipitate renal dysfunction when combined with metformin. - Strong CYP3A4 inhibitors: can raise sitagliptin plasma concentrations.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: monitor renal function and potassium levels. - Diuretics: may affect glucose control and electrolyte balance. - Alcohol: can potentiate metformin‑related lactic acidosis risk.

Frequently asked questions

What is Metformina + Sitagliptina Zentiva K.S. used for?+
Metformina + Sitagliptina Zentiva K.S. is a fixed‑dose oral medication indicated for the treatment of type 2 diabetes mellitus in adults. It helps lower blood glucose levels when used together with diet and exercise, and is often prescribed when metformin alone does not achieve target glycemic control.
How does metformin hydrochloride and sitagliptin work?+
Metformin reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues. Sitagliptin blocks the enzyme DPP‑4, which increases levels of the incretin hormones GLP‑1 and GIP. These hormones stimulate insulin release in a glucose‑dependent manner and suppress glucagon, together enhancing overall glucose regulation.
What is the usual dose of Metformina + Sitagliptina Zentiva K.S.?+
The specific dose and dosing schedule are determined by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.
Is Metformina + Sitagliptina safe during pregnancy or breastfeeding?+
The safety of this combination in pregnancy has not been fully established, and it should only be used if the potential benefits outweigh the risks. Breastfeeding mothers should consult their physician, as metformin is excreted in breast milk while data on sitagliptin are limited.
How do I order Metformina + Sitagliptina from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does this product compare with other antidiabetic options?+
Compared with metformin alone, the addition of sitagliptin provides greater HbA1c reduction and better post‑prandial glucose control. Unlike sulfonylureas, it carries a lower intrinsic risk of hypoglycemia, and unlike GLP‑1 receptor agonists, it is administered orally rather than by injection.
What are the storage and handling requirements?+
Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.
How is Metformina + Sitagliptina administered?+
The medication is taken orally, usually once daily with or after a meal to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a full glass of water and not crushed or chewed unless otherwise directed by a healthcare professional.
What are the most serious risks associated with this therapy?+
The most serious adverse events include lactic acidosis, which is rare but life‑threatening, and severe hypoglycemia when combined with insulin or sulfonylureas. Pancreatitis and rare severe skin reactions have also been reported, so patients should seek immediate medical attention if symptoms arise.
Who should not use Metformina + Sitagliptina?+
Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin or sitagliptin, or a history of lactic acidosis should avoid this medication. It is also contraindicated in individuals with acute or chronic metabolic acidosis, including diabetic ketoacidosis.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metformin Hydrochloride, Sitagliptin
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

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