Metformin Xr Teva

Metformin Hydrochloride, the active ingredient in Metformin XR, is a biguanide presented as an extended-release tablet for oral use. It treats type 2 diabetes mellitus in adult patients. GNH USA supplies Metformin XR as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metformin XR is an oral antidiabetic agent indicated for the management of glucose control in type 2 diabetes mellitus. - Type 2 diabetes mellitus: improves glycaemic control by lowering fasting and post‑prandial blood glucose levels.

Metformin XR may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhea: loose stools, often transient. - Abdominal discomfort: cramping or bloating. - Metallic taste: transient alteration in taste perception. - Headache: mild tension‑type headache. - Decreased appetite: reduced desire to eat.

Serious or Rare Side Effects: - Lactic acidosis: rare but life‑threatening metabolic acidosis. - Severe hypoglycaemia: usually when combined with insulin or sulfonylureas. - Hepatic failure: rare liver dysfunction. - Allergic reactions: rash, pruritus, or angio‑edema. - Vitamin B12 deficiency: long‑term use may lower B12 levels. - Myopathy: muscle pain or weakness in rare cases.

Metformin XR requires careful patient assessment and monitoring to minimise risks. - Renal function monitoring: assess creatinine clearance before initiation and periodically thereafter. - Hepatic function assessment: evaluate liver enzymes in patients with known liver disease. - Risk of lactic acidosis: avoid in patients with hypoxia, severe heart failure, or uncontrolled infection. - Dose adjustment in elderly: start low and titrate slowly. - Concomitant medication review: consider interactions that may affect renal clearance. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Metformin XR can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Iodinated contrast agents: may precipitate acute renal failure and increase lactic acidosis risk. - Cimetidine: can raise metformin plasma concentrations. - Alcohol excess: potentiates risk of lactic acidosis.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may mask hypoglycaemia symptoms. - Diuretics (loop or thiazide): can affect renal clearance of metformin. - ACE inhibitors/ARBs: monitor renal function and electrolytes. - NSAIDs: may impair renal function, increasing metformin exposure. - Corticosteroids: can raise blood glucose, requiring dose adjustments.