Metformin Teva B.V.

Metformin, the active ingredient in Metformin Teva B.V., is a biguanide presented as an oral tablet for oral use. It is used to improve blood glucose control in adults with type 2 diabetes mellitus. GNH USA supplies Metformin Teva B.V. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metformin is indicated for conditions affecting glucose metabolism and insulin sensitivity.

Type 2 diabetes mellitus: improves glycemic control by lowering fasting and post‑prandial blood glucose levels. Prediabetes (impaired fasting glucose): delays progression to overt diabetes when used with lifestyle measures. Polycystic ovary syndrome (off‑label): reduces insulin resistance and may help restore regular menstrual cycles.

Metformin is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects: - Nausea or upset stomach - Diarrhea or loose stools - Abdominal discomfort or cramping - Metallic taste in the mouth - Decreased appetite - Mild weight loss

Serious or Rare Side Effects: - Lactic acidosis, a potentially life‑threatening metabolic disturbance - Severe skin reactions such as Stevens‑Johnson syndrome - Hepatic failure or significant liver enzyme elevation - Marked hypoglycemia when combined with insulin or sulfonylureas - Vitamin B12 deficiency with long‑term use

Metformin requires careful assessment of patient factors and monitoring.

Renal function assessment: evaluate eGFR before initiating and periodically during therapy. Lactic acidosis risk: avoid in patients with severe renal or hepatic impairment. Pregnancy safety: Category B; use only if potential benefits justify the risk. Alcohol consumption: limit intake as it may increase lactic acidosis risk. Drug interaction review: assess concomitant medicines that affect renal clearance or glucose levels. Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Metformin may interact with several medicines, requiring vigilance.

Major Interactions (Avoid): - Iodinated contrast agents: can precipitate acute renal failure and lactic acidosis. - Cimetidine: may increase metformin plasma concentrations. - Alcohol excess: heightens risk of lactic acidosis. - Nephrotoxic drugs (e.g., aminoglycosides, NSAIDs): can impair renal clearance of metformin. - High‑dose vitamin B12 supplements: may mask deficiency symptoms.

Moderate Interactions (Monitor Closely): - Sulfonylureas or insulin: increased risk of hypoglycemia. - Beta‑blockers: may blunt hypoglycemia warning signs. - Thiazide diuretics: can attenuate glucose‑lowering effect. - ACE inhibitors or ARBs: monitor renal function and potassium levels. - Oral contraceptives: may slightly raise metformin levels.