Metformin Teva

Metformin, the active ingredient in Metformin Teva, is a biguanide presented as a tablet for oral use. It treats type 2 diabetes mellitus and is sometimes used off‑label for polycystic ovary syndrome in adults.

GNH USA supplies Metformin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metformin is indicated for conditions that involve impaired glucose regulation or insulin resistance.

Type 2 diabetes mellitus: improves glycemic control by lowering fasting and post‑prandial blood glucose levels. Polycystic ovary syndrome (off‑label): may improve insulin resistance and help restore regular menstrual cycles.

Metformin is generally well tolerated, but a range of adverse reactions have been reported.

Common Side Effects: - Nausea - Diarrhea - Abdominal discomfort - Metallic taste - Loss of appetite - Flatulence

Serious or Rare Side Effects: - Lactic acidosis - Severe skin reactions (e.g., Stevens‑Johnson syndrome) - Hepatic dysfunction - Hypoglycemia when combined with other glucose‑lowering agents - Vitamin B12 deficiency with long‑term use - Acute pancreatitis

Metformin should be used with attention to several safety considerations.

Renal function assessment: avoid use in severe renal impairment (eGFR <30 mL/min/1.73 m²). Hepatic disease monitoring: use cautiously in patients with liver dysfunction. Risk of lactic acidosis: discontinue before radiologic contrast studies or major surgery. Alcohol consumption: limit intake to reduce lactic acidosis risk. Vitamin B12 monitoring: periodic testing recommended for long‑term therapy. Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Metformin may interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Iodinated contrast agents: increase risk of lactic acidosis. - Cimetidine: can raise metformin plasma concentrations. - Alcohol: potentiates lactic acidosis. - Loop diuretics causing dehydration: raise risk of renal impairment. - Certain antiretrovirals (e.g., didanosine): increase toxicity.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may mask hypoglycemia symptoms. - ACE inhibitors or ARBs: monitor renal function and potassium. - Thiazide diuretics: may affect glucose control. - Warfarin: monitor INR as metformin can alter anticoagulant effect. - Oral contraceptives: may slightly increase plasma metformin levels. - Statins: monitor for rare myopathy when combined.