Metformin Teva

Metformin, the active ingredient in Metformin Teva, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus in adult patients, helping to improve glycaemic control as part of a comprehensive management plan that includes diet and exercise.

GNH USA supplies Metformin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metformin Teva is indicated for conditions within the type 2 diabetes therapeutic pathway.

Type 2 diabetes mellitus: lowers elevated blood glucose levels and improves overall glycaemic control. Insulin resistance: enhances peripheral insulin sensitivity, facilitating glucose uptake. Elevated fasting glucose: reduces hepatic glucose output, helping to normalize fasting plasma glucose.

Metformin is associated with a range of adverse reactions that vary in frequency.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Diarrhoea: watery stools, often transient. - Abdominal discomfort: cramping or bloating. - Metallic taste: transient alteration in taste perception. - Loss of appetite: reduced desire to eat. - Flatulence: increased intestinal gas.

Serious or Rare Side Effects: - Lactic acidosis: rare but life‑threatening metabolic acidosis. - Severe skin reactions: such as Stevens‑Johnson syndrome. - Hepatic dysfunction: elevated liver enzymes or hepatitis. - Hypoglycaemia: uncommon when used alone, more likely with concomitant insulin. - Pancreatitis: inflammation of the pancreas. - Vitamin B12 deficiency: long‑term use may reduce absorption.

Metformin requires careful assessment of patient factors and monitoring. - Renal function: evaluate creatinine clearance before initiation and periodically thereafter. - Hepatic disease: avoid in patients with severe liver impairment. - Alcohol consumption: limit intake to reduce risk of lactic acidosis. - Risk of lactic acidosis: monitor for unexplained fatigue, myalgia, dyspnoea, or abdominal pain. - Pregnancy and lactation: discuss benefits and risks with a healthcare professional. - Store at room temperature: keep in the original container, protect from moisture and heat.

Metformin may interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Iodinated contrast agents: can precipitate acute renal failure and increase lactic acidosis risk. - Cimetidine: may raise metformin plasma concentrations. - Alcohol: potentiates risk of lactic acidosis.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may mask hypoglycaemia symptoms. - Diuretics (especially thiazides): can affect renal clearance of metformin. - ACE inhibitors or ARBs: monitor renal function and electrolytes when combined.