Metformin Lek

Metformin, the active ingredient in Metformin Lek, is a biguanide presented as a tablet for oral use. It treats type 2 diabetes mellitus in adults and helps improve blood glucose control.

GNH USA supplies Metformin Lek as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metformin Lek belongs to the biguanide class and is used to manage disorders of glucose metabolism. - Type 2 diabetes mellitus: improves glycemic control and reduces HbA1c levels. - Gestational diabetes mellitus: helps control maternal blood glucose when diet alone is insufficient. - Prediabetes (impaired glucose tolerance): delays progression to overt diabetes by enhancing insulin sensitivity.

Metformin may cause a range of adverse reactions, from mild to serious.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhea: frequent loose stools, especially at treatment initiation. - Abdominal discomfort: cramping or bloating. - Metallic taste: transient alteration of taste perception. - Loss of appetite: reduced desire to eat. - Vitamin B12 deficiency: gradual decrease with long‑term use.

Serious or Rare Side Effects: - Lactic acidosis: rare but potentially fatal metabolic acidosis. - Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatic dysfunction: elevated liver enzymes or hepatitis. - Hypoglycemia: when combined with other glucose‑lowering agents. - Anemia: due to reduced red blood cell production. - Pancreatitis: inflammation of the pancreas.

Before initiating Metformin Lek, several safety considerations should be reviewed. - Renal function monitoring: assess creatinine clearance to avoid accumulation. - Hepatic function assessment: ensure liver enzymes are within normal limits. - Vitamin B12 status: periodic testing for deficiency during long‑term therapy. - Elderly patients: start at lower doses and monitor for intolerance. - Heart failure: avoid in severe cases due to lactic acidosis risk. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Metformin Lek can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Iodinated contrast agents: may precipitate acute renal failure and lactic acidosis. - Cimetidine: can increase metformin plasma concentrations. - Alcohol: potentiates risk of lactic acidosis.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may affect renal function, requiring dose adjustment. - Diuretics: can reduce renal clearance of metformin. - Beta‑blockers: may mask hypoglycemia symptoms. - NSAIDs: may impair renal function and increase metformin levels. - Warfarin: may require INR monitoring due to potential interaction.