Metformax Sr 750

Metformin Hydrochloride, the active ingredient in Metformax Sr 750, is a biguanide presented as a 750 mg tablet for oral use. It treats type 2 diabetes mellitus by lowering blood glucose levels in adult patients.

GNH USA supplies Metformax Sr 750 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metformax Sr 750 (metformin) is used in the management of hyperglycemia associated with type 2 diabetes mellitus.

- Type 2 diabetes mellitus: improves glycemic control and reduces HbA1c levels. - Prediabetes (impaired fasting glucose): helps delay progression to overt diabetes. - Polycystic ovary syndrome (PCOS): may improve insulin resistance and menstrual regularity.

Metformax Sr 750 may cause a range of adverse reactions. Most are mild and transient, but serious events can occur.

Common Side Effects: - Gastrointestinal upset: nausea, vomiting, abdominal discomfort. - Diarrhea: loose stools, sometimes watery. - Metallic taste: persistent metallic sensation in the mouth. - Loss of appetite: reduced desire to eat. - Weight loss: modest reduction in body weight. - Lactic acidosis (rare): symptoms include fatigue, muscle pain, rapid breathing.

Serious or Rare Side Effects: - Severe hypoglycemia (when combined with other glucose‑lowering agents). - Hepatic dysfunction: elevated liver enzymes. - Allergic reactions: rash, pruritus, angioedema. - Vitamin B12 deficiency: neuropathy, anemia with long‑term use.

Metformax Sr 750 should be used with awareness of specific safety considerations.

- Renal function: assess creatinine clearance before initiation and periodically thereafter. - Hepatic disease: avoid in patients with significant liver impairment. - Cardiovascular status: monitor for signs of lactic acidosis in heart failure. - Pregnancy and lactation: weigh potential benefits against risks; consult obstetric guidance. - Concomitant medications: review for drugs that may affect renal clearance or increase lactic acidosis risk. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Metformax Sr 750 can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Iodinated contrast agents: risk of acute renal failure; discontinue metformin before and after imaging. - Cimetidine: may increase metformin plasma concentrations. - Certain antiretrovirals (e.g., didanosine): heightened risk of lactic acidosis.

Moderate Interactions (Monitor Closely): - Diuretics (thiazides, loop): may affect renal function and glucose control. - ACE inhibitors/ARBs: monitor renal function and potassium levels. - Beta‑blockers: can mask hypoglycemia symptoms. - Alcohol: potentiates lactic acidosis risk.