Metex

Methotrexate, the active ingredient in Metex, is a Antimetabolite presented as a Injection for Subcutaneous use. It is employed to treat rheumatoid arthritis, psoriasis, and several malignancies including acute lymphoblastic leukemia, non‑Hodgkin lymphoma, and gestational trophoblastic disease. GNH USA supplies Metex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Methotrexate is an antimetabolite used across autoimmune and oncologic disease families. - Rheumatoid arthritis: reduces disease activity and joint inflammation. - Psoriasis: slows skin cell proliferation and improves plaque lesions. - Acute lymphoblastic leukemia: interferes with malignant cell replication to achieve remission. - Non‑Hodgkin lymphoma: inhibits tumor growth and supports chemotherapy regimens. - Gestational trophoblastic disease: induces trophoblastic cell death to resolve disease.

Methotrexate may cause a range of adverse reactions.

Common Side Effects: - Nausea or vomiting - Fatigue or weakness - Oral mucosal ulceration - Mild liver enzyme elevation - Transient alopecia - Skin rash or photosensitivity

Serious or Rare Side Effects: - Bone marrow suppression leading to pancytopenia - Severe hepatotoxicity or fibrosis - Pulmonary toxicity with interstitial pneumonitis - Life‑threatening infections due to immunosuppression - Renal impairment from crystal nephropathy - Anaphylactoid reactions at injection site

Methotrexate requires careful monitoring and specific safety measures. - Liver monitoring: perform baseline and periodic liver function tests. - Hematologic monitoring: check complete blood counts regularly. - Renal function: assess creatinine clearance before initiation and during therapy. - Pregnancy avoidance: contraindicated in pregnancy (Category X) and requires effective contraception. - Vaccination caution: avoid live vaccines while receiving therapy. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Methotrexate interacts with several drug classes that may alter its efficacy or toxicity.

Major Interactions (Avoid): - Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase methotrexate toxicity. - Penicillins and sulfonamides: potentiate bone marrow suppression. - Live vaccines: risk of severe infection. - High‑dose folic acid supplementation: may reduce therapeutic effect.

Moderate Interactions (Monitor Closely): - Proton pump inhibitors: may increase serum methotrexate levels. - Diuretics (especially thiazides): affect renal clearance. - Oral contraceptives: may reduce methotrexate efficacy in some indications.