Metex

Methotrexate, the active ingredient in Metex, is a antimetabolite (folate antagonist) presented as a sterile injection for intramuscular, intravenous or subcutaneous administration. It is employed to manage autoimmune diseases such as rheumatoid arthritis and severe psoriasis, as well as to treat certain hematologic malignancies and ectopic pregnancy in both adult and pediatric patients.

GNH USA supplies Metex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and specialized clinics worldwide, ensuring quality‑assured products that meet European regulatory standards.

Methotrexate is used in several autoimmune and oncologic conditions where inhibition of folate metabolism is required.

- Rheumatoid arthritis: reduces joint inflammation and slows disease progression. - Psoriasis: improves skin lesions and reduces plaque formation. - Acute lymphoblastic leukemia: induces remission by interfering with malignant cell proliferation. - Non‑Hodgkin lymphoma: contributes to tumor control in combination regimens. - Ectopic pregnancy: facilitates resolution of trophoblastic tissue.

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Fatigue: general tiredness. - Mouth sores: ulceration of oral mucosa. - Elevated liver enzymes: transient increase in hepatic transaminases.

Serious or Rare Side Effects: - Bone marrow suppression: can lead to anemia, leukopenia, thrombocytopenia. - Pulmonary toxicity: interstitial pneumonitis or fibrosis. - Severe hepatotoxicity: progressive liver fibrosis or cirrhosis.

Methotrexate requires careful monitoring and specific safety measures.

- Pregnancy: contraindicated (Category X) due to risk of fetal malformations. - Renal function: assess before use and monitor, as drug is renally excreted. - Liver disease: avoid or use with caution; monitor liver enzymes regularly. - Infection risk: screen for latent infections; avoid in active infections. - Blood counts: perform baseline and periodic CBC to detect marrow suppression. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Methotrexate interacts with several medicines that can alter its safety or effectiveness.

Major Interactions (Avoid): - NSAIDs: increase methotrexate toxicity by reducing renal clearance. - Proton pump inhibitors: may elevate methotrexate levels. - Trimethoprim‑sulfamethoxazole: additive bone marrow suppression. - Live vaccines: risk of severe infection due to immunosuppression.

Moderate Interactions (Monitor Closely): - Azathioprine: combined immunosuppression may increase infection risk. - Penicillins: may reduce renal elimination, monitor levels. - Alcohol: can exacerbate hepatotoxicity, advise limitation.