GNH USA

Europe — EMA

Metazydyna (Trimetazidine Dihydrochloride)

GNH USA supplies Metazydyna (Trimetazidine), a anti‑ischemic metabolic agent for angina pectoris, chronic coronary artery disease and peripheral arterial

Trimetazidine Dihydrochloride

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What is Trimetazidine Dihydrochloride?

Trimetazidine dihydrochloride, the active ingredient in Metazydyna, is an anti‑ischemic metabolic agent presented as an oral tablet for oral use. It is used to manage angina pectoris and related ischemic heart conditions in adults.

GNH USA supplies Metazydyna as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Trimetazidine Dihydrochloride used for?

Metazydyna is indicated for conditions involving myocardial ischemia and peripheral arterial insufficiency.

- Angina pectoris: reduces the frequency and severity of chest pain episodes by improving myocardial energy efficiency. - Chronic coronary artery disease: helps stabilize symptoms and may improve exercise tolerance. - Peripheral arterial disease: supports tissue perfusion by enhancing cellular metabolism in ischemic limbs.

What are the side effects of Trimetazidine Dihydrochloride?

Trimetazidine is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea - Headache - Dizziness - Gastrointestinal discomfort - Constipation - Fatigue

Serious or Rare Side Effects: - Severe allergic reactions (e.g., rash, angioedema) - Liver enzyme elevation - Thrombocytopenia - Extrapyramidal symptoms - Significant hypotension - Arrhythmias

What precautions apply to Trimetazidine Dihydrochloride?

Use of Metazydyna requires careful clinical assessment and monitoring.

- Renal impairment: monitor renal function and adjust therapy as needed. - Hepatic dysfunction: use with caution and observe liver enzymes. - Elderly patients: watch for dizziness or orthostatic symptoms. - Pregnancy and lactation: safety not established; avoid unless clearly needed. - Concomitant anti‑anginal therapy: assess for additive hemodynamic effects. - Store at below 25°C: keep in the original pack, protect from moisture.

What does Trimetazidine Dihydrochloride interact with?

Trimetazidine may interact with several drug classes; monitoring is advised.

Major Interactions (Avoid): - Dopamine antagonists (e.g., metoclopramide): increased risk of extrapyramidal reactions. - Other potent anti‑ischemic agents causing severe hypotension.

Moderate Interactions (Monitor Closely): - Antihypertensive drugs: monitor blood pressure for additive lowering. - Diuretics: watch electrolyte balance and renal function. - Other metabolic modulators: observe for enhanced gastrointestinal effects.

Frequently asked questions

What conditions is Metazydyna used for?+
Metazydyna, containing trimetazidine dihydrochloride, is prescribed for angina pectoris, chronic coronary artery disease, and peripheral arterial disease. It helps improve myocardial energy metabolism and peripheral tissue perfusion in patients with ischemic heart or limb conditions.
How does trimetazidine work in the body?+
Trimetazidine inhibits mitochondrial fatty‑acid β‑oxidation, shifting the heart’s energy production toward glucose oxidation. This metabolic change requires less oxygen, preserving ATP levels during ischemia and reducing chest pain or tissue damage associated with reduced blood flow.
What is the usual dose of Metazydyna?+
The specific dose of Metazydyna is determined by the prescribing physician based on the patient’s clinical condition, age, renal and hepatic function, and response to therapy. Patients should follow the dosage instructions provided by their healthcare professional.
Is Metazydyna safe during pregnancy or breastfeeding?+
Safety data for trimetazidine in pregnancy and lactation are limited. It is generally recommended to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their doctor.
How do I order Metazydyna from GNH USA?+
To request Metazydyna, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.
How does Metazydyna compare with other anti‑anginal drugs?+
Unlike beta‑blockers or calcium‑channel blockers that primarily affect heart rate or vascular tone, Metazydyna acts on cellular metabolism, improving energy efficiency without significantly altering hemodynamics. This makes it a useful adjunct or alternative for patients who cannot tolerate traditional anti‑anginal agents.
What are the storage requirements for Metazydyna?+
Metazydyna should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency throughout its shelf life.
How is Metazydyna administered?+
Metazydyna is taken orally, usually with or without food, as directed by the prescribing physician. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.
What are the most serious risks associated with Metazydyna?+
Serious adverse reactions, although rare, include severe allergic responses, liver enzyme elevations, thrombocytopenia, significant hypotension, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience symptoms such as rash, swelling, jaundice, unexplained bruising, or fainting.
Who should not use Metazydyna?+
Metazydyna is contraindicated in patients with known hypersensitivity to trimetazidine or any of its excipients. Caution is also advised for individuals with severe renal or hepatic impairment, uncontrolled hypotension, or those taking dopamine antagonists that may increase the risk of extrapyramidal side effects.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Trimetazidine Dihydrochloride
Route
Oral Use
Manufacturer
Adamed Pharma S.A.
Origin
EU

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