GNH USA

Europe — EMA

Metapyrin

GNH USA supplies Metapyrin (Metamizole), a pyrazolone analgesic for pain and fever, suitable for hospital formularies. Request a quote for global supply.

Metamizole Sodium

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1
Pack/s

What is Metamizole Sodium?

Metamizole, the active ingredient in Metapyrin, is a pyrazolone presented as an oral dosage form for oral use. It is employed to manage pain and reduce fever in adult patients. GNH USA supplies Metapyrin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium used for?

Metapyrin, a pyrazolone analgesic, acts on the prostaglandin pathway to alleviate discomfort and lower elevated body temperature. - Pain: Provides relief from moderate to severe acute pain. - Fever: Reduces high body temperature in febrile conditions. - Postoperative pain: Controls pain following surgical procedures.

What are the side effects of Metamizole Sodium?

Metapyrin may cause a range of adverse reactions.

Common Side Effects: - Nausea: Mild to moderate upset stomach. - Vomiting: Occasional episodes of emesis. - Dizziness: Transient light‑headedness. - Rash: Skin redness or mild itching.

Serious or Rare Side Effects: - Agranulocytosis: Severe reduction in white blood cells. - Severe allergic reactions (anaphylaxis): Rapid onset of breathing difficulty and swelling. - Stevens‑Johnson syndrome: Rare, serious skin disorder.

What precautions apply to Metamizole Sodium?

Before prescribing Metapyrin, consider the following safety measures. - Assess blood counts: Monitor for neutropenia or agranulocytosis. - Avoid in known hypersensitivity: Do not use in patients with previous allergic reactions to pyrazolones. - Use caution in renal impairment: Adjust therapy if kidney function is reduced. - Use caution in hepatic impairment: Monitor liver enzymes during treatment. - Pregnancy and lactation: Consult a physician before use. - Store at room temperature: Keep in the original pack, protect from moisture.

What does Metamizole Sodium interact with?

Metapyrin can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Concurrent use with other myelotoxic drugs: Increased risk of agranulocytosis. - Combination with sulfonamides: Heightened risk of blood dyscrasias.

Moderate Interactions (Monitor Closely): - NSAIDs: Additive gastrointestinal irritation. - Anticoagulants: Potential for increased bleeding tendency. - ACE inhibitors: May enhance hypotensive effects.

Frequently asked questions

What is Metapyrin used for?+
Metapyrin contains metamizole sodium, a pyrazolone analgesic used to treat moderate to severe pain and to lower fever in adult patients. It is commonly prescribed for acute pain episodes, postoperative discomfort, and febrile conditions where rapid antipyretic action is desired.
How does metamizole work?+
Metamizole works primarily by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins—chemical mediators that cause pain and fever. This inhibition leads to decreased inflammation signals, providing analgesic and antipyretic effects, although the full mechanism is not completely understood.
What is the usual dose of Metapyrin?+
The appropriate dose of Metapyrin is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and individual health factors. Dosage regimens vary, and the prescriber will tailor the amount and frequency to achieve optimal pain relief or fever control.
Is Metapyrin safe during pregnancy or breastfeeding?+
Safety of metamizole during pregnancy and lactation has not been definitively established. Healthcare providers should evaluate the potential benefits against possible risks before prescribing Metapyrin to pregnant or nursing mothers, and alternative therapies may be considered when appropriate.
How do I order Metapyrin from GNH USA?+
To order Metapyrin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.
How does Metapyrin compare with other analgesics?+
Metapyrin (metamizole) differs from traditional NSAIDs by having a distinct pyrazolone structure and a lower incidence of gastrointestinal irritation. However, it carries a unique risk of blood dyscrasias such as agranulocytosis, which is less common with many other analgesics. Clinicians weigh these factors when selecting an appropriate pain management option.
How should Metapyrin be stored and handled?+
Metapyrin should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid environments such as bathrooms.
How is Metapyrin administered?+
Metapyrin is administered orally, typically as a tablet or oral solution, depending on the marketed form. It should be taken with or without food as directed by the prescriber, and patients should follow the dosing schedule provided on the prescription label.
What are the most serious risks associated with Metapyrin?+
The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Prompt medical attention is required if signs of infection, rash, or breathing difficulty develop during therapy.
Who should not use Metapyrin?+
Metapyrin should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, patients with a history of agranulocytosis, and those currently receiving other myelotoxic agents. Caution is also advised for patients with severe liver or kidney impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium
Route
Oral Use
Manufacturer
Goodwill Pharma Nyrt.
Origin
EU

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