GNH USA

Europe — EMA

Metamizole Abz (Metamizole Sodium Monohydrate)

GNH USA supplies Metamizole Abz (Metamizole), a pyrazolone analgesic and antipyretic for pain, fever and postoperative relief. Request a quote for supply.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole, the active ingredient in Metamizole Abz, is a pyrazolone presented as an oral formulation for oral use. It is employed to relieve pain, reduce fever, and provide postoperative analgesia in adult patients. GNH USA supplies Metamizole Abz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Metamizole belongs to the pyrazolone class and is used for conditions that require analgesic or antipyretic therapy.

Pain: provides effective relief of moderate to severe acute pain. Fever: reduces elevated body temperature in febrile states. Postoperative analgesia: helps control pain after surgical procedures.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea or vomiting. - Dizziness or light‑headedness. - Mild skin rash or itching. - Transient low blood pressure. - Temporary reduction in white blood cell count.

Serious or Rare Side Effects: - Agranulocytosis, a potentially life‑threatening drop in neutrophils. - Severe cutaneous reactions such as Stevens‑Johnson syndrome. - Anaphylactic shock or severe allergic response. - Significant liver enzyme elevation. - Hematologic disorders including thrombocytopenia.

What precautions apply to Metamizole Sodium Monohydrate?

Before prescribing Metamizole, clinicians should consider several safety measures.

Assess renal function: adjust use in patients with impaired kidney function. Monitor blood counts: regular hematologic testing is advised due to risk of agranulocytosis. Avoid in known hypersensitivity: discontinue if allergic reactions occur. Use caution in hepatic impairment: liver disease may increase toxicity. Avoid concomitant use with other myelotoxic agents: combined risk of blood dyscrasias. Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

What does Metamizole Sodium Monohydrate interact with?

Metamizole can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Co‑administration with other myelotoxic drugs (e.g., chemotherapy) – heightened risk of severe neutropenia. - Combination with sulfonamide antibiotics – increased incidence of blood dyscrasias.

Moderate Interactions (Monitor Closely): - Concurrent NSAIDs – additive gastrointestinal irritation. - Anticoagulants – potential for enhanced bleeding tendency. - ACE inhibitors – may exacerbate hypotensive effects. - Diuretics – possible reduction in renal clearance of Metamizole.

Frequently asked questions

What is Metamizole Abz used for?+
Metamizole Abz is used to treat moderate to severe pain, to lower elevated body temperature in febrile conditions, and to provide analgesia after surgical procedures. It belongs to the pyrazolone class and offers both analgesic and antipyretic effects.
How does Metamizole work?+
Metamizole works by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins—compounds that mediate pain and fever. This inhibition lowers the perception of pain and helps reset the hypothalamic temperature set‑point, producing antipyretic action.
What is the usual dose of Metamizole?+
The appropriate dose of Metamizole is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. Dosage regimens vary, and the prescriber will tailor the amount and frequency to achieve optimal therapeutic effect.
Is Metamizole safe during pregnancy or breastfeeding?+
Safety data for Metamizole in pregnancy and lactation are limited. It is generally classified as contraindicated or used only when the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Metamizole Abz from GNH USA?+
To place an order, submit an enquiry on the Metamizole Abz product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Metamizole compare with other analgesics such as NSAIDs?+
Metamizole provides analgesic and antipyretic effects similar to NSAIDs but has a distinct safety profile. While NSAIDs commonly cause gastrointestinal irritation and affect platelet function, Metamizole’s primary concern is rare but serious blood dyscrasias like agranulocytosis. Choice of therapy depends on patient risk factors and clinical judgment.
How should Metamizole be stored and handled?+
Metamizole should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.
How is Metamizole administered?+
Metamizole is administered orally, typically as a tablet or liquid preparation, according to the prescriber’s instructions. The medication should be taken with or without food as directed, and the full course should be completed unless advised otherwise by a healthcare professional.
What are the most serious risks associated with Metamizole?+
The most serious risks include agranulocytosis, a severe drop in neutrophil count that can lead to life‑threatening infections, as well as severe skin reactions such as Stevens‑Johnson syndrome and anaphylaxis. Patients should be monitored for signs of infection, rash, or allergic reactions and seek immediate medical attention if they occur.
Who should not use Metamizole?+
Metamizole should not be used by individuals with known hypersensitivity to the drug or other pyrazolones, patients with a history of agranulocytosis, and those receiving other myelotoxic agents unless closely monitored. Caution is also advised in patients with severe liver or kidney impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
Abz-Pharma Gmbh
Origin
EU

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