GNH USA

Europe — EMA

Metamizol Ratiopharm (Metamizole Sodium Monohydrate)

GNH USA supplies Metamizol Ratiopharm (Metamizole sodium), a pyrazolone analgesic and antipyretic for pain, fever and postoperative pain. Request a quote.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium, the active ingredient in Metamizol Ratiopharm, is a pyrazolone presented as an oral tablet for oral use. It is employed to relieve pain and reduce fever in adult patients. The medication belongs to the analgesic and antipyretic therapeutic class and is commonly prescribed for moderate to severe pain, postoperative discomfort, and febrile conditions.

GNH USA supplies Metamizol Ratiopharm as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Metamizole sodium is indicated for conditions where pain or fever requires effective control.

Pain: Provides analgesic relief for moderate to severe acute pain. Fever: Reduces elevated body temperature in febrile states. Postoperative pain: Controls pain following surgical procedures.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole sodium may be associated with a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects: - Nausea - Vomiting - Dizziness - Skin rash

Serious or Rare Side Effects: - Agranulocytosis (severe reduction of white blood cells) - Anaphylactic shock - Stevens‑Johnson syndrome

What precautions apply to Metamizole Sodium Monohydrate?

When prescribing Metamizole sodium, clinicians should observe several precautionary measures to ensure patient safety.

Blood count monitoring: Perform baseline and periodic complete blood counts to detect agranulocytosis early. Hypersensitivity assessment: Avoid use in patients with known allergy to metamizole or other pyrazolones. Pregnancy and lactation: Use only if the potential benefit outweighs unknown risks; safety data are limited. Renal/hepatic impairment: Adjust therapy cautiously and monitor organ function. Concomitant myelotoxic drugs: Exercise caution when combined with other agents that suppress bone marrow. Store at ambient temperature: Keep below 25 °C in the original packaging, protected from moisture.

What does Metamizole Sodium Monohydrate interact with?

Metamizole sodium can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid): - Myelotoxic agents (e.g., cyclophosphamide, chemotherapy): May increase risk of severe blood dyscrasias. - Other NSAIDs or COX inhibitors: Heightened potential for gastrointestinal bleeding and renal impairment. - Anticoagulants (e.g., warfarin): May potentiate anticoagulant effect and increase bleeding risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: Combined use can enhance hypotensive effects. - Antihypertensive agents: May require blood pressure monitoring. - Other pyrazolone derivatives: Potential additive risk of agranulocytosis.

Frequently asked questions

What is Metamizol Ratiopharm used for?+
Metamizol Ratiopharm contains metamizole sodium, a prescription analgesic and antipyretic. It is used to treat moderate to severe pain, reduce fever, and manage postoperative discomfort in adult patients when other therapies are insufficient.
How does Metamizole sodium work?+
Metamizole sodium works by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels decrease pain signal sensitization and lower the hypothalamic set‑point for body temperature, providing analgesic and antipyretic effects.
What is the usual dose of Metamizol Ratiopharm?+
The appropriate dose of Metamizol Ratiopharm is determined by the prescribing clinician based on the patient’s condition, age, weight, and response. Dosage regimens may vary, and patients should follow the specific instructions provided by their healthcare professional.
Is Metamizol Ratiopharm safe during pregnancy or breastfeeding?+
Safety data for metamizole sodium in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.
How do I order Metamizol Ratiopharm from GNH USA?+
To order Metamizol Ratiopharm, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Metamizol compare with other analgesics such as NSAIDs?+
Metamizole belongs to the pyrazolone class, whereas most common over‑the‑counter analgesics are NSAIDs. Both reduce pain and fever, but metamizole has a distinct mechanism and a lower risk of gastrointestinal irritation. However, it carries a rare risk of agranulocytosis, which is not typical for standard NSAIDs.
How should Metamizol Ratiopharm be stored and handled?+
Metamizol Ratiopharm tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.
How is Metamizol Ratiopharm administered?+
Metamizol Ratiopharm is administered orally. The tablets are swallowed whole with water and should be taken exactly as prescribed by a qualified healthcare professional, typically with or without food depending on the prescriber’s guidance.
What are the most serious risks associated with Metamizol?+
The most serious adverse reactions to metamizole include agranulocytosis, a potentially fatal reduction in white blood cells, and severe allergic responses such as anaphylactic shock or Stevens‑Johnson syndrome. Prompt medical attention is required if signs of infection, rash, or breathing difficulties occur.
Who should not use Metamizol Ratiopharm?+
Metamizol Ratiopharm should be avoided in patients with known hypersensitivity to metamizole or other pyrazolones, those with a history of agranulocytosis, and individuals receiving concurrent myelotoxic chemotherapy unless closely monitored. Caution is also advised for patients with severe renal or hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
Ratiopharm Gmbh
Origin
EU

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