Metamizol Dr. Max

Metamizole Sodium Monohydrate, the active ingredient in Metamizol Dr. Max, is a pyrazolone analgesic presented as an oral formulation for systemic use. It is used to relieve pain and reduce fever in adult patients.

GNH USA supplies Metamizol Dr. Max as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metamizole acts as an analgesic and antipyretic within the pyrazolone class, addressing pain and fever pathways. - Pain: provides rapid analgesic relief for acute severe and postoperative pain. - Fever: lowers elevated body temperature in cases of high fever. - Cancer‑related pain: helps manage breakthrough pain in oncology patients when other options are insufficient.

Metamizole may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Dizziness: transient light‑headedness. - Hypotension: occasional drop in blood pressure, especially with rapid IV administration. - Sweating: increased perspiration. - Rash: mild skin irritation. - Leukopenia: reduced white‑blood cell count.

Serious or Rare Side Effects: - Agranulocytosis: severe depletion of neutrophils, potentially life‑threatening. - Anaphylaxis: acute allergic reaction with airway compromise. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatotoxicity: liver enzyme elevation or injury. - Blood dyscrasias: aplastic anemia or thrombocytopenia. - Renal impairment: acute kidney injury in susceptible individuals.

Metamizole should be used with caution and under medical supervision. - Medical supervision: prescribe only after evaluating benefit‑risk ratio. - Blood monitoring: perform regular complete blood counts to detect agranulocytosis early. - Hypersensitivity: avoid in patients with known allergy to pyrazolones. - Renal/hepatic impairment: adjust use in patients with reduced organ function. - Pediatric use: restrict to children only when clearly indicated by a physician. - Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Metamizole can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Other myelosuppressive agents: increased risk of severe blood dyscrasias. - Concurrent NSAIDs: heightened potential for agranulocytosis and gastrointestinal toxicity. - Anticoagulants: may amplify bleeding risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors: possible additive hypotensive effect. - Diuretics: may enhance blood pressure lowering. - Alcohol: can increase dizziness and hypotension. - CYP450 substrates: potential alteration of metabolism requiring dose adjustment.