Metalcaptase

Penicillamine, the active ingredient in Metalcaptase, is a chelating agent presented as an oral dosage form for oral use. It is employed in the management of Wilson disease, rheumatoid arthritis, and cystinuria, helping to remove excess copper and other metals and modulating immune activity.

GNH USA supplies Metalcaptase as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Metalcaptase is a chelating agent indicated for several metabolic and autoimmune conditions. - Wilson disease: reduces copper accumulation, improving hepatic and neurological function. - Rheumatoid arthritis: decreases disease activity by modulating immune response and collagen cross‑linking. - Cystinuria: lowers urinary cystine levels, helping to prevent stone formation.

Adverse reactions may occur with penicillamine therapy.

Common Side Effects: - Nausea and vomiting - Loss of appetite - Metallic taste in the mouth - Fatigue or mild rash

Serious or Rare Side Effects: - Agranulocytosis or severe neutropenia - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Significant liver toxicity or hepatitis

Careful monitoring is required when using Metalcaptase. - Monitor renal function: assess serum creatinine and urine output regularly. - Monitor hepatic function: check liver enzymes and bilirubin periodically. - Avoid in patients with known hypersensitivity to penicillamine. - Use caution with concomitant zinc therapy as it may reduce absorption. - Store at ambient temperature: keep in the original pack, protect from moisture.

Penicillamine may interact with several medicines.

Major Interactions (Avoid): - Zinc supplements: reduce penicillamine absorption; concurrent use should be avoided. - Pyridoxine (vitamin B6) high doses: increase risk of neuropathy; avoid combination.

Moderate Interactions (Monitor Closely): - Methotrexate: may enhance toxicity; monitor blood counts and liver function. - ACE inhibitors: potential additive renal effects; observe renal parameters. - Oral contraceptives: may decrease efficacy; consider alternative contraception.