GNH USA

Europe — EMA

Metagelan (Metamizole Sodium Monohydrate)

GNH USA supplies Metagelan (metamizole sodium), an analgesic for mild to moderate pain and fever. Request a quote for global supply with prompt delivery.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium monohydrate, the active ingredient in Metagelan, is a non‑opioid analgesic (pyrazolone derivative) presented as an oral dosage form for oral use. It is used to relieve mild to moderate pain and reduce fever in adults. GNH USA supplies Metagelan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Metagelan (metamizole sodium monohydrate) is employed for pain and fever management across several clinical situations.

Mild to moderate pain: provides analgesic relief for conditions such as headache, musculoskeletal pain, or postoperative discomfort. Post‑operative pain: helps control pain after surgical procedures. Colic: alleviates visceral pain associated with colic. Fever: reduces elevated body temperature in febrile states.

What are the side effects of Metamizole Sodium Monohydrate?

Metagelan may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Vomiting: occasional episodes. - Dizziness: transient light‑headedness. - Hypotension: mild blood pressure drop. - Skin rash: mild erythema or itching.

Serious or Rare Side Effects: - Agranulocytosis: severe reduction in white blood cells, potentially life‑threatening. - Anaphylaxis: acute allergic reaction with airway compromise. - Severe liver injury: rare hepatic dysfunction. - Blood dyscrasias: including thrombocytopenia or hemolytic anemia.

What precautions apply to Metamizole Sodium Monohydrate?

When prescribing Metagelan, consider the following precautions.

Allergy assessment: avoid use in patients with known hypersensitivity to pyrazolones. Blood monitoring: consider periodic complete blood count, especially during prolonged therapy. Renal impairment: use cautiously; dose adjustment may be required. Hepatic dysfunction: monitor liver function tests. Pregnancy and lactation: safety not established; use only if benefit outweighs risk. Store at ambient temperature: keep below 25°C, in original packaging, protected from moisture.

What does Metamizole Sodium Monohydrate interact with?

Metagelan can interact with several drug classes; awareness of these interactions helps minimize risk.

Major Interactions (Avoid): - Cytotoxic agents (e.g., cyclophosphamide): increased risk of agranulocytosis. - Immunosuppressants (e.g., azathioprine): additive bone marrow suppression. - Anticoagulants (e.g., warfarin): potential enhancement of bleeding risk.

Moderate Interactions (Monitor Closely): - Alcohol: may increase risk of hypotension and gastrointestinal irritation. - Other NSAIDs: additive gastrointestinal toxicity. - Diuretics: may potentiate hypotensive effect.

Frequently asked questions

What is Metagelan used for?+
Metagelan contains metamizole sodium monohydrate and is indicated for the relief of mild to moderate pain, postoperative discomfort, colic‑related visceral pain, and the reduction of fever. It is prescribed for adult patients when a non‑opioid analgesic is appropriate.
How does metamizole sodium work?+
Metamizole sodium acts by non‑selectively inhibiting cyclooxygenase enzymes, which lowers prostaglandin production and reduces peripheral pain signalling. It also has central analgesic effects that are not fully understood, contributing to its antipyretic and analgesic actions.
What is the usual dose of Metagelan?+
The specific dose of Metagelan is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and individual response. Dosage instructions are provided on the prescription label and should be followed exactly as directed.
Is Metagelan safe in pregnancy or breastfeeding?+
Safety data for metamizole sodium during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.
How do I order Metagelan from GNH USA?+
To order Metagelan, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Metagelan compare with other analgesics?+
Metagelan (metamizole) differs from traditional NSAIDs such as ibuprofen or diclofenac by having a distinct pyrazolone structure and a lower incidence of gastrointestinal irritation. Compared with paracetamol, it often provides stronger analgesia for severe pain but carries a rare risk of agranulocytosis, requiring careful monitoring.
How should Metagelan be stored and handled?+
Metagelan should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, and store it out of direct sunlight to maintain stability.
How is Metagelan administered?+
Metagelan is taken orally, usually with a glass of water. It can be taken with or without food, but patients who experience stomach upset may prefer to take it with a meal. The tablet should be swallowed whole and not chewed or crushed.
What are the most serious risks associated with Metagelan?+
The most serious adverse reactions to Metagelan include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic reactions such as anaphylaxis. Patients should be monitored for signs of infection, fever, or allergic symptoms and seek immediate medical attention if they occur.
Who should not use Metagelan?+
Metagelan is contraindicated in individuals with known hypersensitivity to metamizole or other pyrazolone derivatives. It should also be avoided in patients with a history of severe blood dyscrasias, uncontrolled hypertension, or those currently receiving bone‑marrow‑suppressive therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
G.L. Pharma Gmbh
Origin
EU

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