GNH USA

Europe — EMA

Metagelan (Metamizole Sodium Monohydrate)

GNH USA supplies Metagelan (Metamizole Sodium Monohydrate), a pyrazolone analgesic for pain, fever and postoperative discomfort.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole Sodium Monohydrate, the active ingredient in Metagelan, is a pyrazolone analgesic presented as an oral dosage form for oral use. It provides analgesic and antipyretic effects for the treatment of pain and fever in adults.

GNH USA supplies Metagelan as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Metamizole Sodium Monohydrate is employed for pain and fever management by inhibiting prostaglandin synthesis pathways.

- Pain: reduces moderate to severe acute pain. - Fever: lowers elevated body temperature in febrile states. - Postoperative pain: alleviates discomfort following surgical procedures. - Colic: eases visceral pain associated with gastrointestinal colic.

What are the side effects of Metamizole Sodium Monohydrate?

Metagelan may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Dizziness: transient light‑headedness. - Skin rash: erythematous or maculopapular eruptions. - Elevated liver enzymes: transient hepatic enzyme rise.

Serious or Rare Side Effects: - Agranulocytosis: severe reduction in white blood cells, requiring immediate medical attention. - Anaphylactic reaction: rapid onset of airway swelling, hypotension, and urticaria.

What precautions apply to Metamizole Sodium Monohydrate?

Metagelan should be used with caution in specific patient populations and clinical situations.

- Renal impairment: assess kidney function before initiating therapy. - Hepatic disease: monitor liver enzymes during treatment. - Hematologic disorders: avoid in patients with a history of agranulocytosis. - Concomitant NSAIDs: increase risk of gastrointestinal bleeding. - Pregnancy and breastfeeding: use only if the potential benefit justifies the potential risk. - Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture and direct sunlight.

What does Metamizole Sodium Monohydrate interact with?

Metagelan can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened bleeding risk. - Immunosuppressants (e.g., azathioprine): may exacerbate bone‑marrow suppression.

Moderate Interactions (Monitor Closely): - Other NSAIDs or COX inhibitors: additive gastrointestinal toxicity. - Diuretics: possible reduction in renal clearance. - Lithium: increased lithium levels may occur. - Methotrexate: enhanced toxicity risk.

Frequently asked questions

What conditions is Metagelan used to treat?+
Metagelan contains Metamizole Sodium Monohydrate and is indicated for the relief of moderate to severe pain, reduction of fever, postoperative discomfort, and visceral pain such as colic. It is prescribed when other analgesics are insufficient or not tolerated.
How does Metamizole Sodium Monohydrate work?+
The active ingredient inhibits cyclo‑oxygenase enzymes throughout the body, lowering prostaglandin synthesis. This reduces inflammation, pain signaling, and fever generation. Additionally, it influences central nervous system pathways that modulate pain perception, providing both peripheral and central analgesic effects.
What is the usual dose of Metagelan?+
The dosage of Metagelan is determined by the prescribing clinician based on the severity of pain or fever, patient age, weight, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.
Is Metagelan safe to use during pregnancy or breastfeeding?+
Safety data for Metagelan in pregnancy and lactation are limited. It should only be used if the potential therapeutic benefit outweighs any possible risk to the fetus or infant, and only under direct medical supervision.
How do I order Metagelan from GNH USA?+
To place an order, submit an enquiry on the Metagelan product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Metagelan compare with other analgesics?+
Metagelan belongs to the pyrazolone class, offering both analgesic and antipyretic effects similar to NSAIDs but with a distinct mechanism of non‑selective COX inhibition. Compared with opioids, it provides pain relief without the risk of dependence, though it carries a rare risk of agranulocytosis not seen with many NSAIDs.
What are the recommended storage conditions for Metagelan?+
Metagelan should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, direct sunlight, and extreme temperatures to maintain stability.
How is Metagelan administered?+
Metagelan is taken orally as directed by a healthcare professional. It may be administered with or without food, but patients should follow the prescriber’s guidance regarding timing and any accompanying fluids.
What are the most serious risks associated with Metagelan?+
The most serious adverse reactions include agranulocytosis, a severe drop in white blood cells that can lead to infection, and anaphylactic shock. Immediate medical attention is required if symptoms such as fever, sore throat, or signs of allergic reaction appear.
Who should not use Metagelan?+
Metagelan is contraindicated in individuals with a known hypersensitivity to Metamizole or other pyrazolones, patients with a history of agranulocytosis, and those with severe hepatic or renal impairment unless specifically advised by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
G.L. Pharma Gmbh
Origin
EU

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