GNH USA

Europe — EMA

Metafen

GNH USA supplies Metafen (Paracetamol), a non‑opioid analgesic for fever and mild pain. Request a quote for global supply to hospitals, pharmacies

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Metafen, is a Non‑opioid analgesic presented as a tablet for oral use. It treats fever and mild to moderate pain in adults and children when appropriate. GNH USA supplies Metafen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol used for?

Metafen (Paracetamol) works as an analgesic and antipyretic across common pain‑and‑fever pathways. Fever: reduces elevated body temperature associated with infection or inflammation. Headache: alleviates mild to moderate headache symptoms. Musculoskeletal pain: eases sore muscles and joint discomfort. Dental pain: provides relief after dental procedures or toothache.

What are the side effects of Paracetamol?

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea or stomach discomfort. - Mild rash or itching. - Headache. - Dizziness. - Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects: - Severe skin reactions such as Stevens‑Johnson syndrome. - Acute liver failure, especially with overdose. - Blood disorders like thrombocytopenia. - Anaphylaxis or severe allergic reactions.

What precautions apply to Paracetamol?

Use Metafen with awareness of specific safety considerations. - Dose limitation: do not exceed the maximum daily amount recommended by a healthcare professional. - Liver health: avoid use in patients with severe hepatic impairment. - Alcohol consumption: limit alcohol intake while using this product. - Pediatric use: follow age‑appropriate dosing guidelines. - Pregnancy and breastfeeding: consult a physician before use. - Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

What does Paracetamol interact with?

Paracetamol may interact with several medicines; monitoring is advised.

Major Interactions (Avoid): - Warfarin: increased risk of bleeding. - Carbamazepine, phenytoin, or rifampicin: may reduce paracetamol effectiveness. - High‑dose alcohol: heightened liver toxicity.

Moderate Interactions (Monitor Closely): - Other hepatotoxic drugs (e.g., isoniazid, methotrexate). - Oral contraceptives: may slightly increase plasma levels. - Certain antiepileptics: may alter metabolism. - Antifungal agents like fluconazole: potential increase in exposure.

Frequently asked questions

What is Metafen used for?+
Metafen contains paracetamol, which is used to relieve mild to moderate pain such as headache, toothache, muscle aches, and to reduce fever associated with common infections. It is an over‑the‑counter option for short‑term symptom management.
How does paracetamol work in Metafen?+
Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, decreasing the production of prostaglandins that signal pain and regulate body temperature. This central action provides analgesic and antipyretic effects without strong peripheral anti‑inflammatory activity.
What is the usual dose of Metafen?+
The appropriate dose of Metafen is determined by a prescriber or according to the product labeling. Dosage depends on the patient’s age, weight, and clinical condition, and should never exceed the maximum daily amount recommended for paracetamol.
Is Metafen safe during pregnancy or breastfeeding?+
Paracetamol is generally considered compatible with pregnancy and breastfeeding when used at recommended doses, but a healthcare professional should be consulted before use to confirm safety based on individual health status and any other medications.
How do I order Metafen from GNH USA?+
To order Metafen, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Metafen compare with other pain relievers?+
Metafen (paracetamol) differs from NSAIDs such as ibuprofen by lacking significant anti‑inflammatory activity and having a lower risk of gastrointestinal irritation. It is also non‑opioid, making it a safer option for patients who need analgesia without the risks associated with opioid medications.
What are the storage requirements for Metafen?+
Metafen should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and out of reach of children to maintain product stability and potency.
How is Metafen administered?+
Metafen is taken orally, usually with a glass of water. It can be taken with or without food, but if stomach upset occurs, it may be helpful to take it with a small amount of food.
What are the most serious risks associated with Metafen?+
The most serious risks include severe liver injury, especially with overdose or chronic high‑dose use, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if signs of liver dysfunction or severe skin rash develop.
Who should not use Metafen?+
Metafen should be avoided by individuals with known hypersensitivity to paracetamol, severe liver disease, or those who have exceeded the recommended daily dose. Patients on certain medications, such as warfarin or strong enzyme inducers, should consult a healthcare professional before use.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Paracetamol
Route
Oral Use
Manufacturer
Zaklady Farmaceutyczne Polpharma S.A.
Origin
EU

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