Metafen Max (Paracetamol)

Paracetamol, the active ingredient in Metafen Max, is an analgesic, antipyretic presented as an oral tablet for oral use. It is commonly employed to relieve mild to moderate pain and to reduce fever in adults and children when appropriate dosing is applied.

GNH USA supplies Metafen Max as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU manufacturing standards and providing regulatory documentation for global distribution.

Paracetamol is used to manage pain and fever by acting on the central prostaglandin pathway.

- Headache: provides relief from tension‑type or mild migraine pain. - Musculoskeletal pain: reduces discomfort from strains, sprains, and arthritis. - Dental pain: alleviates postoperative or procedural discomfort. - Fever: lowers elevated body temperature associated with infections or inflammatory conditions.

Paracetamol may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: occasional feeling of stomach upset. - Abdominal discomfort: mild stomach pain or indigestion. - Rash: transient skin redness or itching. - Dizziness: brief sensation of light‑headedness. - Increased liver enzymes: mild elevation detectable in laboratory tests. - Sweating: occasional excessive perspiration.

Serious or Rare Side Effects: - Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention. - Hepatotoxicity: potential liver injury, especially with overdose. - Blood disorders: rare cases of agranulocytosis or thrombocytopenia. - Anaphylaxis: life‑threatening allergic reaction with breathing difficulty.

Paracetamol should be used with caution in specific populations and clinical situations.

- Dosage adjustment: reduce dose in patients with hepatic impairment. - Alcohol use: avoid excessive alcohol as it may increase liver risk. - Allergy: discontinue if hypersensitivity reactions such as rash or swelling occur. - Pregnancy: consult a healthcare professional before use during pregnancy. - Concurrent medications: review use with other hepatotoxic drugs. - Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Paracetamol can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Warfarin: increased risk of bleeding. - Isoniazid: heightened hepatotoxic potential. - Phenobarbital: may reduce paracetamol effectiveness.

Moderate Interactions (Monitor Closely): - Alcohol: may exacerbate liver toxicity. - Other paracetamol‑containing products: risk of cumulative overdose. - Carbamazepine: may increase hepatic metabolism of paracetamol.