Metafen

Ibuprofen and Paracetamol, the active ingredients in Metafen, are analgesic and antipyretic agents presented as an oral combination for systemic use. They are used to relieve mild to moderate pain and reduce fever in adults and children when appropriate.

GNH USA supplies Metafen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable sourcing for global healthcare providers.

Metafen, a combination of ibuprofen and paracetamol, acts on pain and fever pathways to provide symptomatic relief.

- Pain relief: reduces mild to moderate pain such as dental, menstrual or postoperative discomfort. - Fever reduction: lowers elevated body temperature in febrile conditions. - Headache: alleviates tension‑type or early migraine headache. - Musculoskeletal pain: eases aches from strains, sprains or arthritis. - Post‑operative discomfort: helps manage pain after minor surgical procedures.

Metafen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Nausea or upset stomach. - Headache. - Dizziness. - Mild skin rash. - Indigestion. - Diarrhoea.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Severe skin reactions such as Stevens‑Johnson syndrome. - Elevated liver enzymes or hepatic injury. - Acute kidney impairment. - Anaphylactic reaction. - Blood dyscrasias (e.g., thrombocytopenia).

Before using Metafen, consider the following safety measures.

- Do not exceed the recommended daily dose: follow prescriber or label guidance. - Take with food or milk: helps reduce gastrointestinal irritation. - Avoid if you have a known allergy to NSAIDs or acetaminophen. - Use caution in patients with liver disease: monitor hepatic function. - Use caution in patients with kidney disease: monitor renal function. - Limit alcohol consumption: it may increase risk of liver injury. - Store at ambient temperature: keep in the original pack, protect from moisture.

Metafen can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or high‑dose aspirin: heightened gastrointestinal toxicity. - Lithium: ibuprofen may raise lithium serum levels.

Moderate Interactions (Monitor Closely): - Antihypertensives: ibuprofen may reduce blood‑pressure‑lowering effect. - Diuretics: possible reduction in renal clearance. - SSRIs: may modestly increase bleeding tendency. - Methotrexate: ibuprofen can raise methotrexate concentrations. - Corticosteroids: combined use may increase ulcer risk.