Metafen Forte

Ibuprofen lysine, the active ingredient in Metafen Forte, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for external use. It relieves musculoskeletal pain, inflammation and sports‑related injuries in adults.

GNH USA supplies Metafen Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen lysine, a topical NSAID, is used to manage conditions involving inflammation and pain in the musculoskeletal system.

Musculoskeletal pain: provides localized relief of pain in muscles and joints. Inflammation: reduces swelling and redness at the site of injury. Sports‑related injuries: helps alleviate pain and inflammation from sprains, strains and overuse.

Topical ibuprofen lysine can cause skin‑related reactions and, rarely, systemic adverse events.

Common Side Effects: - Local skin irritation or redness at the application site. - Itching or mild burning sensation. - Dryness or peeling of the skin. - Pruritus (itchy skin). - Mild erythema.

Serious or Rare Side Effects: - Allergic dermatitis or severe skin rash. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Systemic gastrointestinal ulceration or bleeding. - Acute renal impairment. - Hepatic dysfunction. - Anaphylactic reaction.

When using topical ibuprofen lysine, consider the following safety measures.

Assess skin integrity: avoid application on broken, infected or irritated skin. Limit area: apply to no more than 10 % of body surface at a time. Avoid occlusion: do not cover the treated area with airtight dressings. Monitor for systemic absorption: use caution in patients with renal or hepatic disease. Pregnancy and breastfeeding: consult a healthcare professional before use. Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Topical ibuprofen lysine may interact with systemic medications; awareness of major and moderate interactions is important.

Major Interactions (Avoid): - Concurrent systemic NSAIDs: increased risk of systemic adverse effects. - Anticoagulants (e.g., warfarin): heightened bleeding risk. - Lithium therapy: enhanced lithium toxicity.

Moderate Interactions (Monitor Closely): - Diuretics: may affect renal function. - ACE inhibitors or ARBs: possible reduction in renal perfusion. - Methotrexate: increased plasma levels of methotrexate.