Metafen

Dexketoprofen, the active ingredient in Metafen, is a nonsteroidal anti‑inflammatory drug presented as an oral formulation for systemic use. It is indicated for the relief of mild to moderate acute pain, including musculoskeletal, dental, post‑operative and dysmenorrhea pain. It belongs to the ketoprofen class and provides rapid onset of analgesia, typically within 30 minutes after ingestion.

GNH USA supplies Metafen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Dexketoprofen acts as an NSAID to alleviate pain and inflammation in several acute conditions.

Mild to moderate acute pain: provides analgesic relief for short‑term pain episodes. Musculoskeletal pain: reduces inflammation and improves mobility. Dental pain: eases postoperative discomfort after dental procedures. Post‑operative pain: controls pain following surgery. Dysmenorrhea: alleviates menstrual cramps and associated discomfort.

Dexketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea or upset stomach. - Dyspepsia or heartburn. - Headache. - Dizziness. - Mild increase in blood pressure. - Transient renal function changes.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Severe renal impairment. - Anaphylactic or severe hypersensitivity reactions. - Hepatic failure or significant liver enzyme elevation. - Cardiovascular events such as myocardial infarction or stroke. - Severe skin reactions including Stevens‑Johnson syndrome.

When prescribing or dispensing Metafen, consider the following safety measures.

Assess renal function: adjust use in patients with impaired kidney function. Monitor hepatic function: exercise caution in liver disease. Avoid in known NSAID hypersensitivity: contraindicated for patients with previous allergic reactions. Use with caution in cardiovascular disease: monitor blood pressure and heart status. Use with caution in the elderly: increased risk of gastrointestinal and renal side effects. Store at room temperature: keep in the original pack, protect from moisture and light.

Dexketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Lithium: heightened lithium serum concentrations.

Moderate Interactions (Monitor Closely): - Antihypertensives (e.g., ACE inhibitors, ARBs): may reduce blood pressure control. - Diuretics: potential for reduced renal perfusion. - Corticosteroids: increased risk of gastrointestinal ulceration. - Methotrexate: possible elevation of methotrexate levels. - Cyclosporine: may increase nephrotoxicity risk.