Europe — EMA
Metadoxil (Metadoxine)
GNH USA supplies Metadoxil (Metadoxine), a hepatoprotective agent for alcoholic liver disease, hepatic encephalopathy and liver cirrhosis.
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What is Metadoxine?
Metadoxine, the active ingredient in Metadoxil, is a hepatoprotective agent presented as an oral tablet for oral use. It treats alcoholic liver disease, hepatic encephalopathy and liver cirrhosis in adult patients.
GNH USA supplies Metadoxil as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.
What is Metadoxine used for?
Metadoxil is used in the management of liver disease conditions where hepatic function is compromised.
- Alcoholic liver disease: improves liver enzyme levels and supports recovery of hepatic function. - Hepatic encephalopathy: reduces neurotoxic ammonia accumulation and helps restore mental status. - Liver cirrhosis: aids in stabilizing liver function and may delay progression of fibrosis.
What are the side effects of Metadoxine?
Metadoxil may be associated with a range of adverse reactions, which are categorized by frequency and severity.
Common Side Effects: - Nausea: mild gastrointestinal upset. - Headache: transient mild headache. - Dizziness: occasional light‑headedness. - Diarrhea: loose stools.
Serious or Rare Side Effects: - Hepatic failure: worsening liver function. - Severe allergic reaction: rash, swelling, anaphylaxis. - Blood dyscrasias: neutropenia or thrombocytopenia. - Pancreatitis: abdominal pain with elevated enzymes.
What precautions apply to Metadoxine?
When prescribing Metadoxil, clinicians should consider several precautionary measures to ensure safe use.
- Liver function monitoring: assess baseline and periodic liver enzymes. - Alcohol abstinence: patients should avoid alcohol to maximize benefit. - Renal function: evaluate kidney status in patients with impairment. - Concomitant hepatotoxic drugs: avoid or monitor closely. - Pregnancy and lactation: use only if potential benefit justifies risk. - Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.
What does Metadoxine interact with?
Metadoxil can interact with other medicines, altering its efficacy or safety profile.
Major Interactions (Avoid): - Strong CYP450 inducers: may reduce Metadoxil effectiveness. - High-dose paracetamol: increased risk of hepatotoxicity.
Moderate Interactions (Monitor Closely): - Anticoagulants (warfarin): may enhance bleeding risk. - Other hepatoprotective agents: monitor liver function for additive effects. - Diuretics: watch for electrolyte disturbances.
