Mesulid

Nimesulide, the active ingredient in Mesulid, is a NSAID presented as an oral dosage form for oral use. It treats pain and inflammation in conditions such as osteoarthritis and dysmenorrhea, primarily in adult patients.

GNH USA supplies Mesulid as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Mesulid (nimesulide) is used to manage pain and inflammation associated with musculoskeletal and gynecologic conditions.

- Osteoarthritis: reduces joint pain and improves mobility. - Dysmenorrhea: alleviates menstrual pain and cramps. - Acute pain: provides relief for short‑term postoperative or injury‑related pain. - Inflammatory conditions: decreases swelling and discomfort in soft‑tissue inflammation.

Nimesulide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild stomach upset. - Headache: transient cranial discomfort. - Dizziness: occasional light‑headedness. - Abdominal pain: discomfort in the stomach area. - Diarrhoea: loose stools. - Rash: mild skin irritation.

Serious or Rare Side Effects: - Hepatotoxicity: liver injury presenting with jaundice or elevated enzymes. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Gastrointestinal bleeding: ulceration or bleeding in the digestive tract. - Renal impairment: reduced kidney function or acute failure. - Anaphylaxis: life‑threatening allergic reaction with airway compromise. - Blood dyscrasias: agranulocytosis or thrombocytopenia.

When prescribing Mesulid, clinicians should observe several safety precautions to minimize risk.

- Medical supervision: use only under a prescriber's direction. - Liver disease: avoid in patients with known hepatic impairment. - Renal function: monitor kidney function and adjust use in renal insufficiency. - Concomitant NSAIDs: do not combine with other non‑steroidal anti‑inflammatory drugs. - Gastro‑intestinal protection: consider taking with food to reduce stomach irritation. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Nimesulide can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs: additive gastrointestinal toxicity. - Corticosteroids: heightened risk of ulceration and bleeding. - Lithium: elevated lithium serum levels. - Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors: possible reduction in antihypertensive effect. - Diuretics: risk of renal function decline. - SSRIs: potential for increased bleeding. - Antihypertensives: may diminish blood pressure control. - Oral hypoglycemics: possible alteration of glucose levels.