Mesalazine Sandoz

Mesalazine, the active ingredient in Mesalazine Sandoz, is a 5‑aminosalicylic acid (5‑ASA) presented as an oral tablet for oral use. It is employed to treat ulcerative colitis and Crohn’s disease with colonic involvement, helping to reduce intestinal inflammation in adult patients. It is commonly prescribed as part of maintenance therapy to sustain remission.

GNH USA supplies Mesalazine Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Mesalazine is used in the management of inflammatory bowel disease, targeting colonic inflammation.

- Ulcerative colitis: induces and maintains remission of mild to moderate disease. - Crohn's disease (colonic involvement): reduces intestinal inflammation and helps maintain remission. - Maintenance therapy for ulcerative colitis: sustains disease remission and prevents flare‑ups.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Abdominal pain: cramping or discomfort in the lower abdomen. - Headache: transient mild headache. - Flatulence: increased intestinal gas. - Rash: mild skin irritation. - Altered taste: temporary metallic or bitter taste.

Serious or Rare Side Effects: - Myocarditis: inflammation of heart muscle. - Severe liver injury: marked elevation of liver enzymes. - Pancreatitis: acute inflammation of the pancreas. - Blood dyscrasias: neutropenia or agranulocytosis. - Anaphylaxis: severe allergic reaction. - Exacerbation of colitis: worsening of underlying disease.

Before initiating therapy, consider the following precautions: - Renal monitoring: assess kidney function regularly. - Hepatic monitoring: check liver enzymes periodically. - Disease assessment: evaluate disease activity and severity. - Hypersensitivity: avoid in patients with known allergy to mesalazine or related compounds. - Sulfonamide caution: use carefully in individuals with sulfonamide sensitivity. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Mesalazine may interact with several medicines; awareness of these interactions helps optimize safety.

Major Interactions (Avoid): - Azathioprine: increased risk of myelosuppression. - Warfarin: enhanced anticoagulant effect, may raise INR. - Methotrexate: heightened toxicity and hepatic strain.

Moderate Interactions (Monitor Closely): - NSAIDs: additive gastrointestinal irritation. - Oral contraceptives: possible reduction in contraceptive efficacy. - Lithium: potential increase in serum lithium levels.