GNH USA

Europe — EMA

Memantine Eg

GNH USA supplies Memantine Eg (Memantine), a NMDA receptor antagonist for Alzheimer’s disease. Request a quote for global supply to hospitals and pharmacies

Memantine Hydrochloride

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1
Pack/s

What is Memantine Hydrochloride?

Memantine, the active ingredient in Memantine Eg, is a NMDA receptor antagonist presented as an oral dosage form for oral use. It is used to treat cognitive symptoms of Alzheimer’s disease in adults.

GNH USA supplies Memantine Eg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Memantine Hydrochloride used for?

Memantine acts on the glutamatergic system and is indicated for Alzheimer’s disease across its severity spectrum.

Alzheimer’s disease (mild): modest improvement in memory and cognition. Alzheimer’s disease (moderate): supports daily functional abilities. Alzheimer’s disease (severe): may reduce rate of functional decline.

What are the side effects of Memantine Hydrochloride?

Adverse reactions reported with memantine vary in frequency and severity.

Common Side Effects: - Dizziness: sensation of light‑headedness or unsteadiness. - Headache: mild to moderate pain in the head region. - Constipation: reduced bowel movements or hard stools. - Confusion: transient disorientation or difficulty concentrating.

Serious or Rare Side Effects: - Seizures: occurrence of convulsive episodes. - Allergic reactions: rash, itching, swelling, or anaphylaxis. - Hallucinations: visual or auditory disturbances. - Suicidal thoughts: emergence of depressive ideation or self‑harm urges.

What precautions apply to Memantine Hydrochloride?

Memantine should be used with caution in specific clinical situations.

Renal impairment: adjust dose based on creatinine clearance. Hepatic impairment: monitor liver function and consider dose reduction. History of seizures: use cautiously as the drug may lower seizure threshold. Concomitant NMDA antagonists: avoid combined use to prevent additive effects. Pregnancy and lactation: limited data, weigh potential benefits against risks. Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

What does Memantine Hydrochloride interact with?

Memantine may interact with other medicines that affect the central nervous system or NMDA pathways.

Major Interactions (Avoid): - Amantadine: additive NMDA antagonism may increase adverse CNS effects. - CNS depressants (e.g., benzodiazepines): enhanced sedation or dizziness. - Anticholinergic agents: potential worsening of cognitive impairment.

Moderate Interactions (Monitor Closely): - Diuretics: may raise plasma memantine concentrations. - Antihypertensives: possible additive blood pressure lowering. - Alcohol: may intensify dizziness or confusion.

Frequently asked questions

What is Memantine Eg used for?+
Memantine Eg contains memantine hydrochloride and is prescribed to manage the cognitive symptoms of Alzheimer’s disease. It helps improve memory, attention, and the ability to perform daily activities in patients with mild to severe disease when used as part of a comprehensive treatment plan.
How does memantine work?+
Memantine works by binding to the NMDA receptor’s ion channel at a site separate from the glutamate binding site. This non‑competitive antagonism limits excessive calcium entry into neurons, reducing excitotoxic damage while allowing normal neurotransmission, which supports neuronal health in Alzheimer’s disease.
What is the usual dose of memantine?+
The specific dose of memantine is individualized by the prescribing clinician based on the patient’s condition, renal function, and tolerability. The prescriber determines the appropriate starting dose, titration schedule, and maintenance dose according to current clinical guidelines.
Is memantine safe in pregnancy or breastfeeding?+
Safety data for memantine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers usually advise a careful risk‑benefit assessment before prescribing to pregnant or nursing women.
How do I order Memantine Eg from GNH USA?+
To place an order, submit an enquiry on the Memantine Eg product page at gnh-usa.com, indicating the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does memantine compare with other Alzheimer’s drugs?+
Memantine belongs to the NMDA receptor antagonist class, whereas other approved agents such as donepezil, rivastigmine and galantamine are cholinesterase inhibitors. Memantine is typically used for moderate to severe disease and may be combined with a cholinesterase inhibitor for additive benefit, offering a different mechanism of action.
How should Memantine Eg be stored and handled?+
Memantine Eg should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain stability.
How is Memantine Eg given or administered?+
Memantine Eg is administered orally, usually as a tablet or capsule, and is taken with or without food as directed by the prescriber. Patients should follow the dosing schedule provided by their healthcare professional and swallow the tablet whole with water.
What are the most serious risks to watch for while taking memantine?+
Serious risks include the potential for seizures, severe allergic reactions such as anaphylaxis, and rare neuropsychiatric events like hallucinations or suicidal thoughts. Patients should seek immediate medical attention if they experience any of these symptoms while on memantine.
Who should not use memantine?+
Memantine is contraindicated in patients with known hypersensitivity to memantine or any component of the formulation. Caution is also advised for individuals with severe renal impairment, uncontrolled epilepsy, or those taking other NMDA antagonists, as these conditions may increase the risk of adverse effects.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Memantine Hydrochloride
Route
Oral Use
Manufacturer
Eurogenerics N.V./S.A.
Origin
EU

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