Memantine Eg

Memantine, the active ingredient in Memantine Eg, is a NMDA receptor antagonist presented as an oral formulation for oral use. It treats moderate to severe Alzheimer’s disease in adults.

GNH USA supplies Memantine Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Memantine is an NMDA receptor antagonist used in the management of Alzheimer’s disease.

- Moderate to severe Alzheimer’s disease: helps maintain cognitive function and daily activities in patients with established disease. - Alzheimer’s disease with neuropsychiatric symptoms: may provide modest benefit in reducing agitation and aggression.

Memantine may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects: - Dizziness - Headache - Constipation - Confusion - Fatigue - Hypertension

Serious or Rare Side Effects: - Seizures - Hallucinations - Cardiac arrhythmia - Severe skin reactions such as Stevens‑Johnson syndrome - Suicidal thoughts or behavior - Hepatic injury

When prescribing memantine, clinicians should consider several precautionary measures to ensure safe use. - Renal impairment: dose adjustment may be required in patients with reduced kidney function. - History of seizures: monitor closely for increased seizure activity. - Cardiovascular disease: observe blood pressure and heart rate. - Concurrent NMDA antagonists: avoid combined use to reduce risk of additive neurotoxicity. - Pregnancy and lactation: safety not established; use only if potential benefit justifies potential risk. - Store at room temperature: keep in the original container, protect from moisture and light.

Memantine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Amantadine: additive NMDA antagonism may increase neurotoxicity. - Ketamine: combined NMDA blockade may cause severe central nervous system depression. - Dextromethorphan: concurrent use may enhance adverse CNS effects.

Moderate Interactions (Monitor Closely): - Antihypertensives: memantine may potentiate hypotensive effect. - Diuretics: increased risk of dehydration and electrolyte imbalance. - Anticholinergic agents: may worsen cognitive impairment.