Memantina Cinfa

Memantine Hydrochloride, the active ingredient in Memantina Cinfa, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the treatment of Alzheimer’s disease in adult patients.

GNH USA supplies Memantina Cinfa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Memantine Hydrochloride is used in the management of neurodegenerative conditions, primarily Alzheimer’s disease, by modulating glutamatergic neurotransmission.

- Alzheimer’s disease (mild to moderate): modest improvement in cognition and daily functioning. - Alzheimer’s disease (moderate to severe): helps maintain functional abilities and slows decline. - Behavioral disturbances in Alzheimer’s disease: may reduce agitation and aggression.

Common Side Effects: - Dizziness. - Headache. - Constipation. - Confusion. - Fatigue. - Hypertension.

Serious or Rare Side Effects: - Seizures. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatic dysfunction (elevated transaminases). - Cardiac arrhythmias. - Severe skin reactions. - Suicidal ideation or behavior.

Memantina Cinfa should be used with clinical monitoring and consideration of patient‑specific factors. - Renal impairment: dose adjustment may be required. - Hepatic impairment: use with caution and monitor liver function. - History of seizures: monitor for increased seizure activity. - Concurrent use of other NMDA antagonists: avoid additive neurotoxicity. - Pregnancy: safety unknown; avoid unless benefits outweigh risks. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Memantina Cinfa may interact with several medicines; clinical assessment is advised.

Major Interactions (Avoid): - Amantadine: additive NMDA antagonism may increase neurotoxicity. - Ketamine: combined NMDA blockade can cause severe CNS depression. - Other NMDA antagonists (e.g., dextromethorphan): risk of additive effects.

Moderate Interactions (Monitor Closely): - Antihypertensives: memantine may enhance hypotensive effect. - Diuretics: may increase risk of dehydration and electrolyte imbalance. - Anticholinergics: may worsen cognitive side effects.