GNH USA

Europe — EMA

Melteva

GNH USA supplies Melteva (Ethinylestradiol / Gestodene), a combined oral contraceptive for prevention of pregnancy. Request a quote for global supply.

Ethinylestradiol, Gestodene

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What is Ethinylestradiol, Gestodene?

Ethinylestradiol / Gestodene, the active ingredients in Melteva, are a combined oral contraceptive presented as a tablet for oral use. They prevent pregnancy in women of reproductive age.

GNH USA supplies Melteva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ethinylestradiol, Gestodene used for?

Melteva is a combined oral contraceptive that acts on the hormonal regulation of the menstrual cycle to prevent pregnancy. - Prevention of pregnancy: provides reliable hormonal contraception for women of childbearing potential. - Menstrual cycle regulation: helps achieve more predictable bleeding patterns. - Reduction of ovarian cysts: decreases the formation of functional ovarian cysts. - Management of endometriosis symptoms: alleviates pain associated with endometriosis.

What are the side effects of Ethinylestradiol, Gestodene?

Common Side Effects: - Nausea: mild to moderate stomach upset. - Breast tenderness: transient swelling or discomfort. - Headache: occasional tension‑type headache. - Spotting or breakthrough bleeding: irregular bleeding between periods. - Weight change: slight fluid retention or appetite variation. - Mood changes: mild irritability or emotional fluctuations.

Serious or Rare Side Effects: - Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism. - Arterial thrombosis: stroke or myocardial infarction. - Severe hypertension: sudden increase in blood pressure. - Liver disorders: cholestatic jaundice or hepatic adenoma. - Allergic reactions: rash, itching, or anaphylaxis. - Severe depression or suicidal thoughts.

What precautions apply to Ethinylestradiol, Gestodene?

Before using Melteva, consider the following precautions: - Contraindicated in pregnancy: avoid use during pregnancy. - Smoking over 15 cigarettes per day: increased cardiovascular risk. - History of thromboembolism: avoid due to clotting risk. - Liver disease: use with caution; monitor liver function. - Migraine with aura: contraindicated because of stroke risk. - Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

What does Ethinylestradiol, Gestodene interact with?

Melteva may interact with several medicines that affect its efficacy or safety. Major Interactions (Avoid): - Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): markedly reduce contraceptive effect. - Rifampicin or other strong CYP3A4 inducers: decrease hormone levels, risking pregnancy. - Certain antiretrovirals (e.g., efavirenz): lower plasma concentrations of the contraceptive. Moderate Interactions (Monitor Closely): - Broad‑spectrum antibiotics (e.g., ampicillin): may slightly reduce effectiveness; consider backup contraception. - St. John’s wort: moderate enzyme induction can lower hormone levels. - Antifungal agents (e.g., ketoconazole): may increase hormone concentrations, raising side‑effect risk.

Frequently asked questions

What is Melteva used for?+
Melteva is a combined oral contraceptive indicated for the prevention of pregnancy in women of reproductive age. It works by inhibiting ovulation and creating cervical mucus and endometrial changes that reduce the chance of fertilisation and implantation.
How does Ethinylestradiol and Gestodene work in Melteva?+
Ethinylestradiol (an estrogen) and gestodene (a progestogen) bind to their respective hormone receptors, suppressing the hypothalamic‑pituitary‑ovarian axis. This blocks the luteinising hormone surge needed for ovulation, while the progestogen component thickens cervical mucus and alters the endometrium, preventing sperm penetration and implantation.
What is the usual dose of Melteva?+
The dosing regimen for Melteva is determined by the prescribing healthcare professional. Typically, it is taken once daily as part of a 21‑day active tablet sequence followed by a hormone‑free interval, but the exact schedule should be confirmed with the prescriber.
Is Melteva safe to use during pregnancy or breastfeeding?+
Melteva is contraindicated during pregnancy and should not be started in pregnant women. While limited data exist for breastfeeding, most guidelines advise caution; the benefits and risks should be discussed with a healthcare provider before use while nursing.
How do I order Melteva from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Melteva compare with other combined oral contraceptives?+
Melteva contains ethinyloestradiol and gestodene, a low‑dose estrogen‑progestogen combination that offers a favorable bleeding profile and a lower risk of weight gain compared with some older formulations. Its efficacy and safety are comparable to other second‑generation combined pills, but individual tolerability may vary.
What are the storage and handling requirements for Melteva?+
Melteva tablets should be stored at ambient temperature below 25 °C, in the original blister pack, protected from moisture and direct sunlight. Keep the medication out of reach of children and do not use if the packaging is damaged.
How is Melteva administered?+
Melteva is taken orally, usually once each morning with or without food. It is part of a cyclic regimen that typically includes 21 active tablets followed by a hormone‑free interval, during which withdrawal bleeding occurs.
What are the most serious risks associated with Melteva?+
The most serious risks include venous or arterial thromboembolism, stroke, myocardial infarction, severe hypertension, and liver disorders. Women with a history of clotting disorders, smoking heavily, or having migraine with aura should avoid use and discuss alternatives with their clinician.
Who should not use Melteva?+
Melteva should not be used by women who are pregnant, have a known or suspected estrogen‑dependent tumour, have a history of thromboembolic disease, uncontrolled hypertension, severe liver disease, or migraine with aura. It is also contraindicated in smokers over 15 cigarettes per day.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Ethinylestradiol, Gestodene
Route
Oral Use
Manufacturer
Teva Pharma S.L.U.,
Origin
EU

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