Melteva (Ethinylestradiol, Gestodene)

Ethinylestradiol / Gestodene, the active ingredients in Melteva, are a combined oral contraceptive presented as a tablet for oral use. They prevent pregnancy in women of reproductive age.

GNH USA supplies Melteva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Melteva is a combined oral contraceptive that acts on the hormonal regulation of the menstrual cycle to prevent pregnancy. - Prevention of pregnancy: provides reliable hormonal contraception for women of childbearing potential. - Menstrual cycle regulation: helps achieve more predictable bleeding patterns. - Reduction of ovarian cysts: decreases the formation of functional ovarian cysts. - Management of endometriosis symptoms: alleviates pain associated with endometriosis.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Breast tenderness: transient swelling or discomfort. - Headache: occasional tension‑type headache. - Spotting or breakthrough bleeding: irregular bleeding between periods. - Weight change: slight fluid retention or appetite variation. - Mood changes: mild irritability or emotional fluctuations.

Serious or Rare Side Effects: - Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism. - Arterial thrombosis: stroke or myocardial infarction. - Severe hypertension: sudden increase in blood pressure. - Liver disorders: cholestatic jaundice or hepatic adenoma. - Allergic reactions: rash, itching, or anaphylaxis. - Severe depression or suicidal thoughts.

Before using Melteva, consider the following precautions: - Contraindicated in pregnancy: avoid use during pregnancy. - Smoking over 15 cigarettes per day: increased cardiovascular risk. - History of thromboembolism: avoid due to clotting risk. - Liver disease: use with caution; monitor liver function. - Migraine with aura: contraindicated because of stroke risk. - Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Melteva may interact with several medicines that affect its efficacy or safety. Major Interactions (Avoid): - Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): markedly reduce contraceptive effect. - Rifampicin or other strong CYP3A4 inducers: decrease hormone levels, risking pregnancy. - Certain antiretrovirals (e.g., efavirenz): lower plasma concentrations of the contraceptive. Moderate Interactions (Monitor Closely): - Broad‑spectrum antibiotics (e.g., ampicillin): may slightly reduce effectiveness; consider backup contraception. - St. John’s wort: moderate enzyme induction can lower hormone levels. - Antifungal agents (e.g., ketoconazole): may increase hormone concentrations, raising side‑effect risk.